A personalized multi-channel FES controller based on muscle synergies to support gait rehabilitation after stroke

Simona Ferrante, Noelia Chia Bejarano, Emilia Ambrosini, Antonio Nardone, Anna M. Turcato, Marco Monticone, Giancarlo Ferrigno, Alessandra Pedrocchi

Research output: Contribution to journalArticle

Abstract

It has been largely suggested in neuroscience literature that to generate a vast variety of movements, the Central Nervous System (CNS) recruits a reduced set of coordinated patterns of muscle activities, defined as muscle synergies. Recent neurophysiological studies have recommended the analysis of muscle synergies to finely assess the patient's impairment, to design personalized interventions based on the specific nature of the impairment, and to evaluate the treatment outcomes. In this scope, the aim of this study was to design a personalized multi-channel functional electrical stimulation (FES) controller for gait training, integrating three novel aspects: (1) the FES strategy was based on healthy muscle synergies in order to mimic the neural solutions adopted by the CNS to generate locomotion; (2) the FES strategy was personalized according to an initial locomotion assessment of the patient and was designed to specifically activate the impaired biomechanical functions; (3) the FES strategy was mapped accurately on the altered gait kinematics providing a maximal synchronization between patient's volitional gait and stimulation patterns. The novel intervention was tested on two chronic stroke patients. They underwent a 4-week intervention consisting of 30-min sessions of FES-supported treadmill walking three times per week. The two patients were characterized by a mild gait disability (walking speed > 0.8 m/s) at baseline. However, before treatment both patients presented only three independent muscle synergies during locomotion, resembling two different gait abnormalities. After treatment, the number of extracted synergies became four and they increased their resemblance with the physiological muscle synergies, which indicated a general improvement in muscle coordination. The originally merged synergies seemed to regain their distinct role in locomotion control. The treatment benefits were more evident for one patient, who achieved a clinically important change in dynamic balance (Mini-Best Test increased from 17 to 22) coupled with a very positive perceived treatment effect (GRC = 4). The treatment had started the neuro-motor relearning process also on the second subject, but twelve sessions were not enough to achieve clinically relevant improvements. This attempt to apply the novel theories of neuroscience research in stroke rehabilitation has provided promising results, and deserves to be further investigated in a larger clinical study.

Original languageEnglish
Article number425
JournalFrontiers in Neuroscience
Volume10
Issue numberSEP
DOIs
Publication statusPublished - Sep 16 2016

Keywords

  • Functional electrical stimulation
  • Locomotion
  • Muscle synergies
  • Stroke rehabilitation
  • Treadmill

ASJC Scopus subject areas

  • Neuroscience(all)

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    Ferrante, S., Bejarano, N. C., Ambrosini, E., Nardone, A., Turcato, A. M., Monticone, M., Ferrigno, G., & Pedrocchi, A. (2016). A personalized multi-channel FES controller based on muscle synergies to support gait rehabilitation after stroke. Frontiers in Neuroscience, 10(SEP), [425]. https://doi.org/10.3389/fnins.2016.00425