A perspective on the current treatment strategies for locally advanced rectal cancer

Antonio Avallone; Luigi Aloj; Giuseppe Aprile; Gerardo Rosati; Alfredo Budillon

doi:10.1016/j.biocel.2015.06.002

A perspective on the current treatment strategies for locally advanced rectal cancer

Antonio Avallone, Luigi Aloj, Giuseppe Aprile, Gerardo Rosati, Alfredo Budillon

Istituto Nazionale Tumori Fondazione G. Pascale

Research output: Contribution to journal › Article › peer-review

Abstract

The introduction of total mesorectal excision (TME) and preoperative multimodality treatment have substantially improved the management of rectal cancer reducing local recurrence and increasing sphincter-saving surgery; distant metastases however remain a clinical challenge. Besides, although surgery remains the mainstay for cure of rectal cancer with the multimodality approach (chemotherapy, radiotherapy and surgery) being the standard of care for the majority of rectal cancer patients, there is a need of individualized risk-adapted treatment schemes based on clinico-pathological features because of treatment-induced morbidity and quality of life deterioration. This short viewpoint describes the emerging strategies addressing all these issues.

Original language	English
Pages (from-to)	192-196
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	65
DOIs	https://doi.org/10.1016/j.biocel.2015.06.002
Publication status	Published - Jun 19 2015

Keywords

Adjuvant treatment
Consolidation chemotherapy
Induction chemotherapy
Organ-preservation
Preoperative chemo-radiotherapy (CRT)
Rectal cancer
Short-course radiotherapy (SCRT)

ASJC Scopus subject areas

Biochemistry
Cell Biology

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abstract = "The introduction of total mesorectal excision (TME) and preoperative multimodality treatment have substantially improved the management of rectal cancer reducing local recurrence and increasing sphincter-saving surgery; distant metastases however remain a clinical challenge. Besides, although surgery remains the mainstay for cure of rectal cancer with the multimodality approach (chemotherapy, radiotherapy and surgery) being the standard of care for the majority of rectal cancer patients, there is a need of individualized risk-adapted treatment schemes based on clinico-pathological features because of treatment-induced morbidity and quality of life deterioration. This short viewpoint describes the emerging strategies addressing all these issues.",

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AU - Avallone, Antonio

AU - Aloj, Luigi

AU - Aprile, Giuseppe

AU - Rosati, Gerardo

AU - Budillon, Alfredo

PY - 2015/6/19

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A perspective on the current treatment strategies for locally advanced rectal cancer

Abstract

Keywords

ASJC Scopus subject areas

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