TY - JOUR
T1 - A perspective on the current treatment strategies for locally advanced rectal cancer
AU - Avallone, Antonio
AU - Aloj, Luigi
AU - Aprile, Giuseppe
AU - Rosati, Gerardo
AU - Budillon, Alfredo
PY - 2015/6/19
Y1 - 2015/6/19
N2 - The introduction of total mesorectal excision (TME) and preoperative multimodality treatment have substantially improved the management of rectal cancer reducing local recurrence and increasing sphincter-saving surgery; distant metastases however remain a clinical challenge. Besides, although surgery remains the mainstay for cure of rectal cancer with the multimodality approach (chemotherapy, radiotherapy and surgery) being the standard of care for the majority of rectal cancer patients, there is a need of individualized risk-adapted treatment schemes based on clinico-pathological features because of treatment-induced morbidity and quality of life deterioration. This short viewpoint describes the emerging strategies addressing all these issues.
AB - The introduction of total mesorectal excision (TME) and preoperative multimodality treatment have substantially improved the management of rectal cancer reducing local recurrence and increasing sphincter-saving surgery; distant metastases however remain a clinical challenge. Besides, although surgery remains the mainstay for cure of rectal cancer with the multimodality approach (chemotherapy, radiotherapy and surgery) being the standard of care for the majority of rectal cancer patients, there is a need of individualized risk-adapted treatment schemes based on clinico-pathological features because of treatment-induced morbidity and quality of life deterioration. This short viewpoint describes the emerging strategies addressing all these issues.
KW - Adjuvant treatment
KW - Consolidation chemotherapy
KW - Induction chemotherapy
KW - Organ-preservation
KW - Preoperative chemo-radiotherapy (CRT)
KW - Rectal cancer
KW - Short-course radiotherapy (SCRT)
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U2 - 10.1016/j.biocel.2015.06.002
DO - 10.1016/j.biocel.2015.06.002
M3 - Article
C2 - 26055517
AN - SCOPUS:84935826888
VL - 65
SP - 192
EP - 196
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
SN - 1357-2725
ER -