A perspective on the current treatment strategies for locally advanced rectal cancer

Antonio Avallone, Luigi Aloj, Giuseppe Aprile, Gerardo Rosati, Alfredo Budillon

Research output: Contribution to journalArticlepeer-review


The introduction of total mesorectal excision (TME) and preoperative multimodality treatment have substantially improved the management of rectal cancer reducing local recurrence and increasing sphincter-saving surgery; distant metastases however remain a clinical challenge. Besides, although surgery remains the mainstay for cure of rectal cancer with the multimodality approach (chemotherapy, radiotherapy and surgery) being the standard of care for the majority of rectal cancer patients, there is a need of individualized risk-adapted treatment schemes based on clinico-pathological features because of treatment-induced morbidity and quality of life deterioration. This short viewpoint describes the emerging strategies addressing all these issues.

Original languageEnglish
Pages (from-to)192-196
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Publication statusPublished - Jun 19 2015


  • Adjuvant treatment
  • Consolidation chemotherapy
  • Induction chemotherapy
  • Organ-preservation
  • Preoperative chemo-radiotherapy (CRT)
  • Rectal cancer
  • Short-course radiotherapy (SCRT)

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology


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