A pharmacological study on the possible mechanisms underlying changes in TSH secretion in aged male rats

G. Di Renzo, E. Galbiati, M. Taglialatela, A. Fatatis, L. Canzoniero, L. Annunziato

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Abstract

Serum TSH,T3 and T4 levels and TSH release from anterior pituitary gland were studied in young and aged male rats. Furthermore, the effect of a chronic treatment with phosphatidylserine on TSH secretion was investigated in aged animals. Serum TSH levels were significantly higher in aged rats than those of young animals whereas T3 and T4 concentrations did not show any change. TSH release from hemipituitaries was greater in young animals. The chronic treatment with phosphatidylserine was able to reduce the increase of TSH secretion found in aged animals. These results seem to suggest that an impairment of dopaminergic mechanisms involved in the regulation of TSH secretion occurs in aged male rats.

Original languageEnglish
Pages (from-to)377-385
Number of pages9
JournalNeuroendocrinology Letters
Volume13
Issue number5
Publication statusPublished - 1991

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)

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    Di Renzo, G., Galbiati, E., Taglialatela, M., Fatatis, A., Canzoniero, L., & Annunziato, L. (1991). A pharmacological study on the possible mechanisms underlying changes in TSH secretion in aged male rats. Neuroendocrinology Letters, 13(5), 377-385.