Abstract
Serum TSH,T3 and T4 levels and TSH release from anterior pituitary gland were studied in young and aged male rats. Furthermore, the effect of a chronic treatment with phosphatidylserine on TSH secretion was investigated in aged animals. Serum TSH levels were significantly higher in aged rats than those of young animals whereas T3 and T4 concentrations did not show any change. TSH release from hemipituitaries was greater in young animals. The chronic treatment with phosphatidylserine was able to reduce the increase of TSH secretion found in aged animals. These results seem to suggest that an impairment of dopaminergic mechanisms involved in the regulation of TSH secretion occurs in aged male rats.
| Original language | English |
|---|---|
| Pages (from-to) | 377-385 |
| Number of pages | 9 |
| Journal | Neuroendocrinology Letters |
| Volume | 13 |
| Issue number | 5 |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Endocrinology
- Neuroscience(all)
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A pharmacological study on the possible mechanisms underlying changes in TSH secretion in aged male rats. / Di Renzo, G.; Galbiati, E.; Taglialatela, M.; Fatatis, A.; Canzoniero, L.; Annunziato, L.
In: Neuroendocrinology Letters, Vol. 13, No. 5, 1991, p. 377-385.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A pharmacological study on the possible mechanisms underlying changes in TSH secretion in aged male rats
AU - Di Renzo, G.
AU - Galbiati, E.
AU - Taglialatela, M.
AU - Fatatis, A.
AU - Canzoniero, L.
AU - Annunziato, L.
PY - 1991
Y1 - 1991
N2 - Serum TSH,T3 and T4 levels and TSH release from anterior pituitary gland were studied in young and aged male rats. Furthermore, the effect of a chronic treatment with phosphatidylserine on TSH secretion was investigated in aged animals. Serum TSH levels were significantly higher in aged rats than those of young animals whereas T3 and T4 concentrations did not show any change. TSH release from hemipituitaries was greater in young animals. The chronic treatment with phosphatidylserine was able to reduce the increase of TSH secretion found in aged animals. These results seem to suggest that an impairment of dopaminergic mechanisms involved in the regulation of TSH secretion occurs in aged male rats.
AB - Serum TSH,T3 and T4 levels and TSH release from anterior pituitary gland were studied in young and aged male rats. Furthermore, the effect of a chronic treatment with phosphatidylserine on TSH secretion was investigated in aged animals. Serum TSH levels were significantly higher in aged rats than those of young animals whereas T3 and T4 concentrations did not show any change. TSH release from hemipituitaries was greater in young animals. The chronic treatment with phosphatidylserine was able to reduce the increase of TSH secretion found in aged animals. These results seem to suggest that an impairment of dopaminergic mechanisms involved in the regulation of TSH secretion occurs in aged male rats.
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UR - http://www.scopus.com/inward/citedby.url?scp=0025955585&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0025955585
VL - 13
SP - 377
EP - 385
JO - Neuroendocrinology Letters
JF - Neuroendocrinology Letters
SN - 0172-780X
IS - 5
ER -