Abstract
Background: There is pre-clinical evidence of synergism between cisplatin (P) and temozolomide (T) due to higher inhibition by T of O6-alkyl- guanine-alkyltransferase (AGAT), an enzyme involved in the mismatch repair system. T and P are active against malignant gliomas while thalidomide (TH) is emerging as an inhibitor of angiogenesis. Patients and Methods: Triplets of patients with malignant brain tumors received escalating doses of P, T and TH up to the dose-limiting-toxicity (DLT) and the maximal tolerated dose (MTD). Results: Seventeen patients were enrolled and a total of 74 cycles were delivered. The MTD was P 75 mg/m2 day 1 and T 150 mg/m2 days 1 to 5 every 21 days with a concomitant 200 mg total daily dose of TH. DLT events were G4 thrombocytopenia and febrile neutropenia. Conclusion: Concomitant administration of P 75 mg/m2 day 1, T 150 mg/m2 days 1 to 5 every 21 days and concomitant TH at a total daily dose of 150 mg is feasible and safe. Early efficacy data are encouraging and a phase II study is ongoing.
Original language | English |
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Pages (from-to) | 1019-1024 |
Number of pages | 6 |
Journal | Anticancer Research |
Volume | 27 |
Issue number | 2 |
Publication status | Published - Mar 2007 |
Keywords
- Brain
- Chemotherapy
- Cisplatin
- Gliomas
- Malignant
- Temozolomide
- Thalidomide
- Tumors
ASJC Scopus subject areas
- Cancer Research
- Oncology