A phase II, randomized, double-blind study of zibotentan (ZD4054) in combination with carboplatin/paclitaxel versus placebo in combination with carboplatin/paclitaxel in patients with advanced ovarian cancer sensitive to platinum-based chemotherapy (AGO-OVAR 2.14)

F. Cognetti, A. Bagnato, N. Colombo, A. Savarese, G. Scambia, J. Sehouli, P. Wimberger, R. Sorio, P. Harter, E. Mari, S. McIntosh, F. Nathan, K. Pemberton, K. Baumann

Research output: Contribution to journalArticlepeer-review

Abstract

Background. In platinum-sensitive relapsed ovarian cancer, paclitaxel plus carboplatin is a standard secondline treatment. Zibotentan (ZD4054) is an oral, specific ETA-receptor antagonist with demonstrated antitumour activity in xenograft models of human ovarian cancer. Methods. In this Phase II, randomized, placebo-controlled study, patientswith relapsed ovarian cancer sensitive to platinum-based chemotherapy received zibotentan 10 mg or placebo once-daily, plus paclitaxel 175 mg/m2 iv followed by carboplatin iv (AUC 5) on day 1 of every 3-week cycle for a maximum of eight cycles. The primary endpoint was progression-free survival (PFS), evaluated by Response Evaluation Criteria In Solid Tumours (RECIST). Secondary and exploratory endpoints included objective tumour response rate, tumour size, CA-125/ RECIST progression, and safety and tolerability. Results. A total of 120 patientswere randomized (zibotentan: n=59; placebo: n=61). Addition of zibotentan 10 mg/day to carboplatin and paclitaxel did not improve PFS compared with placebo (median PFS, 7.6 versus 10.0 months, respectively; HR=1.46, [80% CI: 1.10-1.94]; P=0.0870). No improvements in any of the secondary or exploratory efficacy endpoints were observed for patients receiving zibotentan comparedwith placebo.Median duration of total treatment exposure was 6.7 months. Total chemotherapy dose received was lower for zibotentan-treated versus placebo-treated patients (carboplatin: -16%; paclitaxel: -14%). The most common adverse events in the zibotentan arm were anaemia, nausea, alopecia, headache and neutropenia (43-48% of patients).

Original languageEnglish
Pages (from-to)31-37
Number of pages7
JournalGynecologic Oncology
Volume130
Issue number1
DOIs
Publication statusPublished - Jul 2013

Keywords

  • Advanced
  • Cancer
  • Carboplatin/paclitaxel
  • Ovarian
  • ZD4054
  • Zibotentan

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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