A phase II trial on alpha-interferon α IFN) effect in patients with monoclonal igm gammopathy

B. Rotoli, A. De Renzo, F. Frigeri, S. Buffardi, R. Marceno, A. M. Cavallaro, P. Ruggeri, V. Liso, P. Musto, A. Andriani, V. Callea, M. Pizzuti, E. Iannitto, R. Cimino, S. Molica, P. Citarrella, C. Musolino, S. Guarino, G. Lucarelli, A. EspinosaL. Del Vecchio

Research output: Contribution to journalArticle

Abstract

Waldenstrom's macroglobulinemia (WM) is an incurable disorder of B cells. Following occasional reports of response to α interferon (IFN) and in view of its effectiveness in hairy cell leukemia, we tested this agent in a relatively large group (n = 88) of patients who had an IgM monoclonal component (MC) greater than 10 g/1. Thirty eight patients had a MC >30 g/1 and were classified as Waldenstrom's macroglobulinemia (WM), while fifty had either WM in an early stage or an IgM monoclonal gammopathy of undeterminated significance (all of them operationally classified as IgM-MGUS). All patients received IFN 3 MU/day for one month and then 3 times/week. Response to treatment was mainly based on MC reduction in two consecutive determinations (>50%: major response; 25-50%: minor response). Of 36 evaluable WM patients, 12 had a major and 6 a minor response; of 41 evaluable IgM-MGUS patients, 2 had a major and 6 a minor response. In WM patients with a major response, MC reduction was associated with disappearance of hyperviscosity symptoms, raised Hb level and reduced bone marrow lymphoplasmacytosis. At the dose used, tolerance was excellent in the majority of patients; only 15% withdrew from the study due to side effects. Although single cases and very small series have already been reported, no large study collecting quantitative data on the effects of α IFN in WM has been published so far. Our results suggest that IFN treatment is not indicated for patients with a low monoclonal component, while it is of clinical benefit in about 50% of patients with IgM >30 g/1.

Original languageEnglish
Pages (from-to)463-469
Number of pages7
JournalLeukemia and Lymphoma
Volume13
Issue number5-6
DOIs
Publication statusPublished - 1994

Keywords

  • Alpha IFN gammopathy
  • Waldenström's macroglobulinemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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    Rotoli, B., De Renzo, A., Frigeri, F., Buffardi, S., Marceno, R., Cavallaro, A. M., Ruggeri, P., Liso, V., Musto, P., Andriani, A., Callea, V., Pizzuti, M., Iannitto, E., Cimino, R., Molica, S., Citarrella, P., Musolino, C., Guarino, S., Lucarelli, G., ... Del Vecchio, L. (1994). A phase II trial on alpha-interferon α IFN) effect in patients with monoclonal igm gammopathy. Leukemia and Lymphoma, 13(5-6), 463-469. https://doi.org/10.3109/10428199409049636