A phosphatase associated with metastasis of colorectal cancer

S. Saha, A. Bardelli, P. Buckhaults, V. E. Velculescu, C. Rago, B. St. Croix, K. E. Romans, M. A. Choti, C. Lengauer, K. W. Kinzler, B. Vogelstein

Research output: Contribution to journalArticlepeer-review

Abstract

To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.

Original languageEnglish
Pages (from-to)1343-1346
Number of pages4
JournalScience
Volume294
Issue number5545
DOIs
Publication statusPublished - Nov 9 2001

ASJC Scopus subject areas

  • General

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