A physical model of the intracranial system for the study of the mechanisms of the cerebral blood flow autoregulation

Antonio Ficola, Mario Luca Fravolini, Carmelo Anile

Research output: Contribution to journalArticlepeer-review

Abstract

This paper introduces a novel physical model of the intracranial system, which was built with the specific purpose of gaining a better insight into the fundamental mechanisms involved in the cerebral circulation. Specifically, the phenomena of passive autoregulation of the blood flow and the variation of the intracranial compliance as a function of the mean intracranial pressure have been investigated. The physical model allows to go beyond state-of-the-art mathematical models that are often based on strong assumptions or simplifications on the physical mechanisms governing the cerebral circulation. Indeed, the physical model based on passive components was able to correctly replicate some fundamental mechanisms of the blood flow autoregulation. In particular, it allows to highlight the role of the venous outflow, which behaves as a Starling resistor. The physical model can be employed as a demonstrator for educational purpose and to test the behavior of shunts for the therapy of hydrocephalus.

Original languageEnglish
Article number8520862
Pages (from-to)67166-67175
Number of pages10
JournalIEEE Access
Volume6
DOIs
Publication statusPublished - Jan 1 2018

Keywords

  • intracranial compliance
  • Intracranial system
  • passive autoregulation
  • physical model
  • Starling resistor

ASJC Scopus subject areas

  • Computer Science(all)
  • Materials Science(all)
  • Engineering(all)

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