Abstract
Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.
| Original language | English |
|---|---|
| Journal | Integrative Cancer Therapies |
| Volume | 18 |
| DOIs | |
| Publication status | Published - May 1 2019 |
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Keywords
- adenomas
- biomarkers
- FAP
- hereditary tumors
- low-inflammatory diet
- microbiota
- prevention
- quality of life
ASJC Scopus subject areas
- Oncology
- Complementary and alternative medicine
Cite this
A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis : Protocol Description and Preliminary Results. / Pasanisi, Patrizia; Gariboldi, Manuela; Verderio, Paolo; Signoroni, Stefano; Mancini, Andrea; Rivoltini, Licia; Milione, Massimo; Masci, Enzo; Ciniselli, Chiara Maura; Bruno, Eleonora; Macciotta, Alessandra; Belfiore, Antonino; Ricci, Maria Teresa; Gargano, Giuliana; Morelli, Daniele; Apolone, Giovanni; Vitellaro, Marco.
In: Integrative Cancer Therapies, Vol. 18, 01.05.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis
T2 - Protocol Description and Preliminary Results
AU - Pasanisi, Patrizia
AU - Gariboldi, Manuela
AU - Verderio, Paolo
AU - Signoroni, Stefano
AU - Mancini, Andrea
AU - Rivoltini, Licia
AU - Milione, Massimo
AU - Masci, Enzo
AU - Ciniselli, Chiara Maura
AU - Bruno, Eleonora
AU - Macciotta, Alessandra
AU - Belfiore, Antonino
AU - Ricci, Maria Teresa
AU - Gargano, Giuliana
AU - Morelli, Daniele
AU - Apolone, Giovanni
AU - Vitellaro, Marco
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.
AB - Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.
KW - adenomas
KW - biomarkers
KW - FAP
KW - hereditary tumors
KW - low-inflammatory diet
KW - microbiota
KW - prevention
KW - quality of life
UR - http://www.scopus.com/inward/record.url?scp=85065227373&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85065227373&partnerID=8YFLogxK
U2 - 10.1177/1534735419846400
DO - 10.1177/1534735419846400
M3 - Article
C2 - 31055940
AN - SCOPUS:85065227373
VL - 18
JO - Integrative Cancer Therapies
JF - Integrative Cancer Therapies
SN - 1534-7354
ER -