A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results

Patrizia Pasanisi, Manuela Gariboldi, Paolo Verderio, Stefano Signoroni, Andrea Mancini, Licia Rivoltini, Massimo Milione, Enzo Masci, Chiara Maura Ciniselli, Eleonora Bruno, Alessandra Macciotta, Antonino Belfiore, Maria Teresa Ricci, Giuliana Gargano, Daniele Morelli, Giovanni Apolone, Marco Vitellaro

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Abstract

Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.

Original languageEnglish
JournalIntegrative Cancer Therapies
Volume18
DOIs
Publication statusPublished - May 1 2019

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Adenomatous Polyposis Coli
Quality of Life
Inflammation
Mediterranean Diet
Diet
Food
Colectomy
Fabaceae
Vegetables
Epidemiologic Studies
Colorectal Neoplasms
Fruit
Fishes
Outcome Assessment (Health Care)
Prospective Studies
Safety

Keywords

  • adenomas
  • biomarkers
  • FAP
  • hereditary tumors
  • low-inflammatory diet
  • microbiota
  • prevention
  • quality of life

ASJC Scopus subject areas

  • Oncology
  • Complementary and alternative medicine

Cite this

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title = "A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis: Protocol Description and Preliminary Results",
abstract = "Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.",
keywords = "adenomas, biomarkers, FAP, hereditary tumors, low-inflammatory diet, microbiota, prevention, quality of life",
author = "Patrizia Pasanisi and Manuela Gariboldi and Paolo Verderio and Stefano Signoroni and Andrea Mancini and Licia Rivoltini and Massimo Milione and Enzo Masci and Ciniselli, {Chiara Maura} and Eleonora Bruno and Alessandra Macciotta and Antonino Belfiore and Ricci, {Maria Teresa} and Giuliana Gargano and Daniele Morelli and Giovanni Apolone and Marco Vitellaro",
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T1 - A Pilot Low-Inflammatory Dietary Intervention to Reduce Inflammation and Improve Quality of Life in Patients With Familial Adenomatous Polyposis

T2 - Protocol Description and Preliminary Results

AU - Pasanisi, Patrizia

AU - Gariboldi, Manuela

AU - Verderio, Paolo

AU - Signoroni, Stefano

AU - Mancini, Andrea

AU - Rivoltini, Licia

AU - Milione, Massimo

AU - Masci, Enzo

AU - Ciniselli, Chiara Maura

AU - Bruno, Eleonora

AU - Macciotta, Alessandra

AU - Belfiore, Antonino

AU - Ricci, Maria Teresa

AU - Gargano, Giuliana

AU - Morelli, Daniele

AU - Apolone, Giovanni

AU - Vitellaro, Marco

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.

AB - Patients with familial adenomatous polyposis (FAP) depend on a lifelong endoscopic surveillance programme and prophylactic surgery, and usually suffer nutritional problems. Intestinal inflammation has been linked to both FAP and colorectal cancer. Epidemiological studies show a relationship between diet and inflammation. Preventive dietary recommendations for FAP patients are so far lacking. We have designed a nonrandomized prospective pilot study on FAP patients to assess whether a low-inflammatory diet based on the Mediterranean diet principles and recipes, by interacting with the microbiota, reduces gastrointestinal markers of inflammation and improves quality of life. This report describes the scientific protocol of the study and reports the participants’ adherence to the proposed dietary recommendations. Thirty-four FAP patients older than 18 years, bearing the APC pathogenic variant, who underwent prophylactic total colectomy with ileo-rectal anastomosis were eligible into the study. During the 3-month dietary intervention, they reported improvements in their consumption of Mediterranean foods (vegetables, fruits, fish, and legumes), and a reduction in pro-inflammatory foods (red/processed meat and sweets); this led to a significant increase in their adherence to the Mediterranean diet. The improvement was accompanied by a decrease in the number of diarrhoeal discharges. These preliminary results are encouraging with regard to feasibility, dietary outcome measures, and safety.

KW - adenomas

KW - biomarkers

KW - FAP

KW - hereditary tumors

KW - low-inflammatory diet

KW - microbiota

KW - prevention

KW - quality of life

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