Studio pilota "placebo-controlled" e "cross-over" per valutare sicurezza ed efficacia della alfalattoalbumina in pazienti con mioclono cronico

Translated title of the contribution: A pilot randomized, double-blind, placebo-controlled, cross-over trial of the whey protein alfa-lactoalbumin in chronic cortical myoclonus

M. Pezzella, L. Errichiello, L. Santulli, G. Giudizioso, A. Ferrari, G. Prato, S. Vari, M. M. Mancardi, M. G. Baglietto, S. Striano, P. Mainardi, P. Striano

Research output: Contribution to journalArticle

Abstract

Chronic cortical myoclonus may be due to multiple aetiological factors enhancing the excitability of motor cortex. The possibility that an abnormal serotonin transmission is involved in the generation of epileptic seizures and myoclonus has been discussed for a long time. In particular, previous research has demonstrated a reduction of tryptophan and other serotonin metabolites in animal models and in patients with progressive myoclonus epilepsy. Alpha-lactoalbumin (ALAC) is a whey protein rich in tryptophan, naturally present in human milk, and showing the highest tryptophan/neutral amino acids (LNAAs) ratio among all food-derived proteins. We conducted a pragmatic, double-blind, placebo-controlled, cross-over trial, followed by an open-label extension, to evaluate the tolerability and the antimyoclonic efficacy of ALAC in patients with chronic cortical myoclonus of various aetiologies. ALAC was generally well tolerated but statistical analysis failed to identify any significant benefit on myoclonus in our series. However, our data showed that ALAC therapy was associated to a striking improvement of sleep quality and depressive symptoms in these patients.

Original languageItalian
Pages (from-to)125-127
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number144
Publication statusPublished - May 2012

Fingerprint

Myoclonus
Cross-Over Studies
Placebos
Tryptophan
Serotonin
Progressive Myoclonic Epilepsy
Neutral Amino Acids
Motor Cortex
Human Milk
Quality Improvement
Epilepsy
Sleep
Animal Models
Depression
Food
Whey Proteins
Research
Proteins
Therapeutics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Studio pilota "placebo-controlled" e "cross-over" per valutare sicurezza ed efficacia della alfalattoalbumina in pazienti con mioclono cronico. / Pezzella, M.; Errichiello, L.; Santulli, L.; Giudizioso, G.; Ferrari, A.; Prato, G.; Vari, S.; Mancardi, M. M.; Baglietto, M. G.; Striano, S.; Mainardi, P.; Striano, P.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 144, 05.2012, p. 125-127.

Research output: Contribution to journalArticle

Pezzella, M, Errichiello, L, Santulli, L, Giudizioso, G, Ferrari, A, Prato, G, Vari, S, Mancardi, MM, Baglietto, MG, Striano, S, Mainardi, P & Striano, P 2012, 'Studio pilota "placebo-controlled" e "cross-over" per valutare sicurezza ed efficacia della alfalattoalbumina in pazienti con mioclono cronico', Bollettino - Lega Italiana contro l'Epilessia, no. 144, pp. 125-127.
Pezzella, M. ; Errichiello, L. ; Santulli, L. ; Giudizioso, G. ; Ferrari, A. ; Prato, G. ; Vari, S. ; Mancardi, M. M. ; Baglietto, M. G. ; Striano, S. ; Mainardi, P. ; Striano, P. / Studio pilota "placebo-controlled" e "cross-over" per valutare sicurezza ed efficacia della alfalattoalbumina in pazienti con mioclono cronico. In: Bollettino - Lega Italiana contro l'Epilessia. 2012 ; No. 144. pp. 125-127.
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