A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

Gian Domenico Borasio, W. Robberecht, P. N. Leigh, J. Emile, R. J. Guiloff, F. Jerusalem, V. Silani, P. E. Vos, J. H J Wokke, T. Dobbins

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Abstract

To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.

Original languageEnglish
Pages (from-to)583-586
Number of pages4
JournalNeurology
Volume51
Issue number2
Publication statusPublished - Aug 1998

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Borasio, G. D., Robberecht, W., Leigh, P. N., Emile, J., Guiloff, R. J., Jerusalem, F., Silani, V., Vos, P. E., Wokke, J. H. J., & Dobbins, T. (1998). A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis. Neurology, 51(2), 583-586.