A polygenic model with common variants may predict lung adenocarcinoma risk in humans

Antonella Galvan, Felicia S. Falvella, Monica Spinola, Elisa Frullanti, Vera P. Leoni, Sara Noci, Maria R. Alonso, Anna Zolin, Elena Spada, Silvano Milani, Ugo Pastorino, Matteo Incarbone, Luigi Santambrogio, Anna Gonzalez Neira, Tommaso A. Dragani

Research output: Contribution to journalArticle

Abstract

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.

Original languageEnglish
Pages (from-to)2327-2330
Number of pages4
JournalInternational Journal of Cancer
Volume123
Issue number10
DOIs
Publication statusPublished - Nov 15 2008

Keywords

  • Genetic susceptibility
  • Genome-wide association
  • Lung adenocarcinoma
  • Single-nucleotide polymorphisms
  • Smoking

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

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    Galvan, A., Falvella, F. S., Spinola, M., Frullanti, E., Leoni, V. P., Noci, S., Alonso, M. R., Zolin, A., Spada, E., Milani, S., Pastorino, U., Incarbone, M., Santambrogio, L., Neira, A. G., & Dragani, T. A. (2008). A polygenic model with common variants may predict lung adenocarcinoma risk in humans. International Journal of Cancer, 123(10), 2327-2330. https://doi.org/10.1002/ijc.23789