Abstract
Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.
Original language | English |
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Pages (from-to) | 2327-2330 |
Number of pages | 4 |
Journal | International Journal of Cancer |
Volume | 123 |
Issue number | 10 |
DOIs | |
Publication status | Published - Nov 15 2008 |
Keywords
- Genetic susceptibility
- Genome-wide association
- Lung adenocarcinoma
- Single-nucleotide polymorphisms
- Smoking
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Medicine(all)