A polygenic model with common variants may predict lung adenocarcinoma risk in humans

Antonella Galvan; Felicia S. Falvella; Monica Spinola; Elisa Frullanti; Vera P. Leoni; Sara Noci; Maria R. Alonso; Anna Zolin; Elena Spada; Silvano Milani; Ugo Pastorino; Matteo Incarbone; Luigi Santambrogio; Anna Gonzalez Neira; Tommaso A. Dragani

doi:10.1002/ijc.23789

A polygenic model with common variants may predict lung adenocarcinoma risk in humans

Antonella Galvan, Felicia S. Falvella, Monica Spinola, Elisa Frullanti, Vera P. Leoni, Sara Noci, Maria R. Alonso, Anna Zolin, Elena Spada, Silvano Milani, Ugo Pastorino, Matteo Incarbone, Luigi Santambrogio, Anna Gonzalez Neira, Tommaso A. Dragani

Research output: Contribution to journal › Article › peer-review

Abstract

Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.

Original language	English
Pages (from-to)	2327-2330
Number of pages	4
Journal	International Journal of Cancer
Volume	123
Issue number	10
DOIs	https://doi.org/10.1002/ijc.23789
Publication status	Published - Nov 15 2008

Keywords

Genetic susceptibility
Genome-wide association
Lung adenocarcinoma
Single-nucleotide polymorphisms
Smoking

ASJC Scopus subject areas

Cancer Research
Oncology
Medicine(all)

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10.1002/ijc.23789

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Galvan, A., Falvella, F. S., Spinola, M., Frullanti, E., Leoni, V. P., Noci, S., Alonso, M. R., Zolin, A., Spada, E., Milani, S., Pastorino, U., Incarbone, M., Santambrogio, L., Neira, A. G., & Dragani, T. A. (2008). A polygenic model with common variants may predict lung adenocarcinoma risk in humans. International Journal of Cancer, 123(10), 2327-2330. https://doi.org/10.1002/ijc.23789

Galvan, A, Falvella, FS, Spinola, M, Frullanti, E, Leoni, VP, Noci, S, Alonso, MR, Zolin, A, Spada, E, Milani, S, Pastorino, U , Incarbone, M, Santambrogio, L, Neira, AG & Dragani, TA 2008, 'A polygenic model with common variants may predict lung adenocarcinoma risk in humans', International Journal of Cancer, vol. 123, no. 10, pp. 2327-2330. https://doi.org/10.1002/ijc.23789

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abstract = "Genome-wide screening for genetic loci associated with risk of lung adenocarcinoma (ADCA) was carried out in pooled DNA using the Illumina 300K single-nucleotide polymorphism (SNP) array, in a joint analysis of 2 Italian case-control series matched by age, gender and smoking habit. The rare allele carrier status of 8 SNPs was associated with a decreased lung ADCA risk [odds ratios (OR): 0.6-0.8]. In a polygenic model characterized by additive and interchangeable effects, individuals carrying 2 to 6 rare alleles at these 8 SNPs showed a significant trend toward a decreased risk of lung ADCA (up to OR of 0.3). These results suggest the relevance of a polygenic model in the modulation of individual risk of lung ADCA in the general population.",

keywords = "Genetic susceptibility, Genome-wide association, Lung adenocarcinoma, Single-nucleotide polymorphisms, Smoking",

author = "Antonella Galvan and Falvella, {Felicia S.} and Monica Spinola and Elisa Frullanti and Leoni, {Vera P.} and Sara Noci and Alonso, {Maria R.} and Anna Zolin and Elena Spada and Silvano Milani and Ugo Pastorino and Matteo Incarbone and Luigi Santambrogio and Neira, {Anna Gonzalez} and Dragani, {Tommaso A.}",

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AU - Leoni, Vera P.

AU - Noci, Sara

AU - Alonso, Maria R.

AU - Zolin, Anna

AU - Spada, Elena

AU - Milani, Silvano

AU - Pastorino, Ugo

AU - Incarbone, Matteo

AU - Santambrogio, Luigi

AU - Neira, Anna Gonzalez

AU - Dragani, Tommaso A.

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KW - Single-nucleotide polymorphisms

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A polygenic model with common variants may predict lung adenocarcinoma risk in humans

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