A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: A genetic study and evaluation of circulating IGF-1 from the "treviso Longeva (TRELONG)" study

Diego Albani, Sara Batelli, Letizia Polito, Angelica Vittori, Marzia Pesaresi, Giovanni Battista Gajo, Sergio De Angeli, Andrea Zanardo, Maurizio Gallucci, Gianluigi Forloni

Research output: Contribution to journalArticle

Abstract

Background. An attenuation of the insulin-like growth factor 1 (IGF-1) signaling has been associated with elongation of the lifespan in simple metazoan organisms and in rodents. In humans, IGF-1 level has an age-related modulation with a lower concentration in the elderly, depending on hormonal and genetic factors affecting the IGF-1 receptor gene (IGF-1R). Methods. In an elderly population from North-eastern Italy (n = 668 subjects, age range 70106 years) we investigated the IGF-1R polymorphism G3174A (rs2229765) and the plasma concentration of free IGF-1. Frequency distributions were compared using 2-test "Goodness of Fit" test, and means were compared by one-way analysis of variance (ANOVA); multiple regression analysis was performed using JMP7 for SAS software (SAS Institute, USA). The limit of significance for genetic and biochemical comparison was set at = 0.05. Results. Males showed an age-related increase in the A-allele of rs2229765 and a change in the plasma level of IGF-1, which dropped significantly after 85 years of age (85+ group). In the male 85+ group, A/A homozygous subjects had the lowest plasma IGF-1 level. We found no clear correlation between rs2229765 genotype and IGF-1 in the females. Conclusion. These findings confirm the importance of the rs2229765 minor allele as a genetic predisposing factor for longevity in Italy where a sex-specific pattern for IGF-1 attenuation with ageing was found.

Original languageEnglish
Article number19
JournalBMC Geriatrics
Volume9
Issue number1
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Geriatrics and Gerontology

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