A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children

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We investigated the possible association between PRF1 gene polymorphisms and HIV-1 vertical transmission in Brazilian children by analyzing PRF1 gene coding and untranslated regions in 173 perinatally infected children (HIV+), 51 exposed uninfected (HIV-), and 171 HIV-unexposed uninfected children. Seven single nucleotide polymorphisms were identified in our samples. The rs885822 C allele and CC genotype were significantly more frequent in HIV-negative than in HIV-positive patients and associated with a protective effect toward HIV vertical transmission.

Original languageEnglish
Pages (from-to)535-537
Number of pages3
JournalAIDS (London, England)
Issue number4
Publication statusPublished - Feb 20 2011


ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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