A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We investigated the possible association between PRF1 gene polymorphisms and HIV-1 vertical transmission in Brazilian children by analyzing PRF1 gene coding and untranslated regions in 173 perinatally infected children (HIV+), 51 exposed uninfected (HIV-), and 171 HIV-unexposed uninfected children. Seven single nucleotide polymorphisms were identified in our samples. The rs885822 C allele and CC genotype were significantly more frequent in HIV-negative than in HIV-positive patients and associated with a protective effect toward HIV vertical transmission.

Original languageEnglish
Pages (from-to)535-537
Number of pages3
JournalAIDS (London, England)
Volume25
Issue number4
DOIs
Publication statusPublished - Feb 20 2011

Fingerprint

HIV-1
HIV
Genes
Untranslated Regions
Single Nucleotide Polymorphism
Alleles
Genotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Cite this

A polymorphism in PRF1 gene is associated with HIV-1 vertical transmission in Brazilian children. / Padovan, Lara; Segat, Ludovica; Crovella, Sergio.

In: AIDS (London, England), Vol. 25, No. 4, 20.02.2011, p. 535-537.

Research output: Contribution to journalArticle

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