A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia

Giusi Prencipe, Cinzia Auriti, Rita Inglese, Rita Devito, Maria Paola Ronchetti, Giulio Seganti, Lucilla Ravà, Marcello Orzalesi, Fabrizio De Benedetti

Research output: Contribution to journalArticle

Abstract

Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the-173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung tissue from preterm infants. Serum MIF levels were measured by ELISA at d 1 after birth. MIF levels were increased [median (interquartile range), 71.01 (44.9-162.3) ng/mL], particularly in those infants with RDS [110.4 (59.4-239.2) ng/mL] compared with healthy adults [2.4 (1.2-5.0) ng/mL], (p <0.001). The MIF - 173*C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95% CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03). In conclusion, these data show that MIF expression is increased in lung and serum of preterm infants and suggest that the high producing MIF - 173*C allele may be a protective factor for BPD.

Original languageEnglish
Pages (from-to)142-147
Number of pages6
JournalPediatric Research
Volume69
Issue number2
DOIs
Publication statusPublished - Feb 2011

Fingerprint

Macrophage Migration-Inhibitory Factors
Bronchopulmonary Dysplasia
Premature Infants
Lung
Serum
Alleles
Fetal Development
Artificial Respiration
Enzyme-Linked Immunosorbent Assay
Parturition
Prospective Studies
Cytokines
Oxygen
Morbidity
Mortality
Incidence

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia. / Prencipe, Giusi; Auriti, Cinzia; Inglese, Rita; Devito, Rita; Ronchetti, Maria Paola; Seganti, Giulio; Ravà, Lucilla; Orzalesi, Marcello; De Benedetti, Fabrizio.

In: Pediatric Research, Vol. 69, No. 2, 02.2011, p. 142-147.

Research output: Contribution to journalArticle

@article{143a63003fe5449e9a9eb83e90ac9fa3,
title = "A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia",
abstract = "Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the-173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung tissue from preterm infants. Serum MIF levels were measured by ELISA at d 1 after birth. MIF levels were increased [median (interquartile range), 71.01 (44.9-162.3) ng/mL], particularly in those infants with RDS [110.4 (59.4-239.2) ng/mL] compared with healthy adults [2.4 (1.2-5.0) ng/mL], (p <0.001). The MIF - 173*C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95{\%} CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03). In conclusion, these data show that MIF expression is increased in lung and serum of preterm infants and suggest that the high producing MIF - 173*C allele may be a protective factor for BPD.",
author = "Giusi Prencipe and Cinzia Auriti and Rita Inglese and Rita Devito and Ronchetti, {Maria Paola} and Giulio Seganti and Lucilla Rav{\`a} and Marcello Orzalesi and {De Benedetti}, Fabrizio",
year = "2011",
month = "2",
doi = "10.1203/PDR.0b013e3182042496",
language = "English",
volume = "69",
pages = "142--147",
journal = "Pediatric Research",
issn = "0031-3998",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - A polymorphism in the macrophage migration inhibitory factor promoter is associated with bronchopulmonary dysplasia

AU - Prencipe, Giusi

AU - Auriti, Cinzia

AU - Inglese, Rita

AU - Devito, Rita

AU - Ronchetti, Maria Paola

AU - Seganti, Giulio

AU - Ravà, Lucilla

AU - Orzalesi, Marcello

AU - De Benedetti, Fabrizio

PY - 2011/2

Y1 - 2011/2

N2 - Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the-173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung tissue from preterm infants. Serum MIF levels were measured by ELISA at d 1 after birth. MIF levels were increased [median (interquartile range), 71.01 (44.9-162.3) ng/mL], particularly in those infants with RDS [110.4 (59.4-239.2) ng/mL] compared with healthy adults [2.4 (1.2-5.0) ng/mL], (p <0.001). The MIF - 173*C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95% CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03). In conclusion, these data show that MIF expression is increased in lung and serum of preterm infants and suggest that the high producing MIF - 173*C allele may be a protective factor for BPD.

AB - Bronchopulmonary dysplasia (BPD) is a common adverse outcome of prematurity, causing severe morbidity and mortality. The cytokine macrophage migration inhibitory factor (MIF) has been recently shown to favor murine fetal lung development. In this prospective study, we evaluate the expression of MIF in the lung and in the serum of preterm infants (n = 50) and investigate whether the-173 G/C MIF promoter polymorphism is associated with the risk of BPD (n = 103). MIF was highly expressed in lung tissue from preterm infants. Serum MIF levels were measured by ELISA at d 1 after birth. MIF levels were increased [median (interquartile range), 71.01 (44.9-162.3) ng/mL], particularly in those infants with RDS [110.4 (59.4-239.2) ng/mL] compared with healthy adults [2.4 (1.2-5.0) ng/mL], (p <0.001). The MIF - 173*C allele, which predisposes to higher MIF production, was associated with a lower incidence of BPD (OR, 0.2; 95% CI, 0.04-0.93), independently from mechanical ventilation and oxygen exposure (p = 0.03). In conclusion, these data show that MIF expression is increased in lung and serum of preterm infants and suggest that the high producing MIF - 173*C allele may be a protective factor for BPD.

UR - http://www.scopus.com/inward/record.url?scp=79951628207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951628207&partnerID=8YFLogxK

U2 - 10.1203/PDR.0b013e3182042496

DO - 10.1203/PDR.0b013e3182042496

M3 - Article

C2 - 21045753

AN - SCOPUS:79951628207

VL - 69

SP - 142

EP - 147

JO - Pediatric Research

JF - Pediatric Research

SN - 0031-3998

IS - 2

ER -