A population-based analysis of temporal perioperative complication rates after minimally invasive radical prostatectomy

Jan Schmitges, Quoc Dien Trinh, Firas Abdollah, Maxine Sun, Marco Bianchi, Lars Budäus, Kevin Zorn, Paul Perotte, Thorsten Schlomm, Alexander Haese, Francesco Montorsi, Mani Menon, Markus Graefen, Pierre I. Karakiewicz

Research output: Contribution to journalArticle

Abstract

Background: Existing population-based reports on complication rates after minimally invasive radical prostatectomy (MIRP) did not address temporal trends. Objective: To examine contemporary temporal trends in perioperative MIRP outcomes. Design, setting, and participants: Between 2001 and 2007, 4387 patients undergoing MIRP were identified using the Nationwide Inpatient Sample. Measurements: To examine the rates and trends of intraoperative and postoperative complications, transfusion rates, length of stay in excess of the median, and in-hospital mortality. We tested the effect of the late (2006-2007) versus the early (2001-2005) study period on all outcomes using multivariable logistic regression models controlled for clustering among hospitals. Results and limitations: Intraoperative and postoperative complications decreased from 7.0% to 0.8% (p <0.001) and from 28.5% to 8.7% (p <0.001), respectively. Transfusion rates decreased from 3.5% to 2.1% (p = 0.3). Hospital length of stay >2 d decreased from 56% to 15% (p <0.001). In multivariable analyses, intraoperative (odds ratio [OR]: 0.41; p = 0.002) and postoperative (OR: 0.65; p = 0.007) complications were less frequent in the late versus the early study period. Late study period patients were less likely to stay >2 d than early study period patients (OR: 0.34; p > 0.001). Limitations of these findings include the lack of adjustment for several patient variables including disease characteristics, surgeon variables including surgeon caseload, and the restriction to in-hospital events. Conclusions: Our analyses demonstrate that in-hospital complication rates and length of stay after MIRP decreased over time. This implies that temporal differences specific to complication rates after MIRP must be considered when comparisons are made with other radical prostatectomy techniques.

Original languageEnglish
Pages (from-to)564-571
Number of pages8
JournalEuropean Urology
Volume60
Issue number3
DOIs
Publication statusPublished - Sep 2011

Keywords

  • Blood transfusion
  • Minimally invasive surgery
  • Perioperative complications
  • Prostatectomy
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

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    Schmitges, J., Trinh, Q. D., Abdollah, F., Sun, M., Bianchi, M., Budäus, L., Zorn, K., Perotte, P., Schlomm, T., Haese, A., Montorsi, F., Menon, M., Graefen, M., & Karakiewicz, P. I. (2011). A population-based analysis of temporal perioperative complication rates after minimally invasive radical prostatectomy. European Urology, 60(3), 564-571. https://doi.org/10.1016/j.eururo.2011.06.036