A population-based comparison of European and North American sinonasal cancer survival

A.A. Unsal, S. Kılıç, P.M. Dubal, S. Baredes, J.A. Eloy, EUROCARE-5 Working Group

Research output: Contribution to journalArticlepeer-review


Objective: Sinonasal cancers (SNC) are rare, thus limiting previous prognostic studies on a multinational level. The aim of this study is to utilize two population-based datasets to compare prognoses for SNC between the United States (US) and Europe. Methods: The European Cancer Registry (EUROCARE) database and the United States National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database were searched to identify survival of patients diagnosed with SNC between 1990 and 2007. Relative survival (RS) data were stratified by age group, gender, geographic location, and diagnostic time period. Results: 12,541 SNC cases were identified in EUROCARE, while SEER identified 4,312. Males comprised the majority in Europe (62.3%) and the US (58.3%). Most patients were over 55 years in Europe (77.0%) and the US (69.5%). Age over 75 was a statistically significant poor prognostic indicator for 5-year RS in the US (48.2%; 95% CI = [43.9, 52.4]) and Europe (38.5%; [34.7, 42.7]). Female gender imparted a favorable 5-year RS in all regions except in Central Europe. By region, the US had the highest 5-year RS (58.8%; [56.4, 61.1]) and Eastern Europe had the lowest 5-year RS (37.1%; [34.0, 40.6]). The aggregate European 5-year RS was 48.1% [46.4, 49.8]. Conclusion: SNC in Europe and the US most commonly affects males and individuals over the age of 55 years. Male gender and age over 75 are poor prognostic factors at 5 years. Five-year RS in the US is higher than the 5-year European aggregate RS. © 2017 Elsevier B.V.
Original languageEnglish
Pages (from-to)815-824
Number of pages10
JournalAuris Nasus Larynx
Issue number4
Publication statusPublished - 2018
Externally publishedYes


  • Europe
  • International
  • Population-based
  • Relative survival
  • SEER
  • Sinonasal cancer
  • Surveillance Epidemiology End Results
  • Survival
  • United States
  • adult
  • cancer prognosis
  • cancer registry
  • cancer survival
  • diagnosis
  • Eastern Europe
  • female
  • gender
  • human
  • male
  • national health organization
  • overall survival
  • prognosis
  • adenocarcinoma
  • adolescent
  • age
  • age distribution
  • aged
  • factual database
  • head and neck tumor
  • Ireland
  • middle aged
  • mortality
  • North America
  • nose tumor
  • paranasal sinus tumor
  • register
  • sex factor
  • sex ratio
  • squamous cell carcinoma
  • survival rate
  • United Kingdom
  • young adult
  • Adenocarcinoma
  • Adolescent
  • Adult
  • Age Distribution
  • Age Factors
  • Aged
  • Carcinoma, Squamous Cell
  • Databases, Factual
  • Europe, Eastern
  • Female
  • Head and Neck Neoplasms
  • Humans
  • Male
  • Middle Aged
  • Nose Neoplasms
  • Paranasal Sinus Neoplasms
  • Prognosis
  • Registries
  • SEER Program
  • Sex Distribution
  • Sex Factors
  • Survival Rate
  • Young Adult


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