A population-based study of active and drug-resistant epilepsies in Northern Italy

G. Giussani, Valentina Canelli, Elisa Bianchi, C. Franchi, Alessandro Nobili, Giuseppe Erba, Ettore Beghi, Elio Agostoni, Larissa Airoldi, Francesco Basso, Marialuisa Carpanelli, Mariolina Di Stefano, Andrea Magnoni, Ottaviano Martinelli, A. Rigamonti, Andrea Salmaggi, Lorenzo Stanzani, Cristina Volpe, Nicoletta Zanotta, Claudio ZuccaMarco Agudio, Flavio Arienti, Graziano Rocco Arrigoni, Giancarlo Balestra, Piercarla Ballabio, Stefano Marco Balossi, Maria Rita Baratti, Fabrizia Enrica Barteselli, Fausto Bellani, Mauro Bellani, Gianpiero Bellini, Pier Aldo Beretta, Roberto Beretta, Massimo Bergamini, Annalisa Bertella, Francesco Bertolini, Rolando Bevilacqua, Marcellino Bianchi, Patrizia Bigiolli, Giuseppe Binda, Gigliola Biondelli, Libero Bodega, Edoardo Giovanni Bolis, Marco Vincenzo Carlo Bolla, Carlo Ambrogio Bonacina, Marco Bonfanti, Fausta Borghetti, Roberto Brambilla, Wilma Brancaleone, Francesco Brusadelli, Sabine Bub, Giovanna Caccia, Myriam Caglio, Carlo Calvi Rossi, Daniela Capra, Davide Carone, Giuseppe Carì, Silvio Carrera, Rosalia Cavenago, Maria Luisa Cecchetti, Bice Antonella Centonze, Fabio Cereghini, Ciro Cerrone, Maria Pia Ciappetta, Bruno Cogliati, Ombretta Colombano, Alberto Colombo, Daniela Colombo, Maria Lia Corti, Nicla Cremonini, Marco Crippa, Rolando Antonio Crippa, Mario Crotta, Salvatore Curto, Patrizia Daielli, Domenico De Gilio, Giuseppe Pasquale De Pascalis, Elena Decet, Luigi Della Morte, Felice Duvia, Antonia Favorito, Roberto Ferrario, Luigi Fezzi, Angela Laura Finzi, Bruno Ugo Fiorentino, Agnese Fornaciari, Silvana Franceschetti, Fabio Fulconis, Giovanni Fumagalli, Maurizio Fumagalli, Giuseppe Galbiati, Carlo Andrea Galimberti, Donatella Gecchele, Barbara Ghiazza, Paolo Ghislanzoni, Laura Gioffredi, Taraneh Hassibi, Simone Julita, Giuseppe Leone, Claudio Levi, Giovanni Locatelli, Anna Alessandra Locati, Enrico Giovanni Longhi, Ingrid Lukacova, Mauro Giovanni Manfroi, Paola Manzoni, Claudio Marcolini, Fabio Minicucci, Mohammed Safwan Martini, Rita Masperi, Sussele Mayan, Valeria Mazzoleni, Antonio Menga, Fiorella Merlini, Enrico Messina, Marta Micheli, Rocco Micò, Andrea Millul, Barbara Montini, Alberto Palazzuolo, Silvano Primo Panzeri, Giovanni Passoni, Laura Pensotti, Maria Marcella Petrone, Roberto Pezzuto, Elisabetta Pigazzini, Nicoletta Pirovano, Margherita Pontiggia, Roberto Pozzi, Carlo Quadrelli, Filomena Rampello, Marco Realini, Giovanni Righetti, Cesare Ripa, Sonia Rivetta, Antonino Romeo, Carlo Rota, Tiziana Rusconi, Andrea Santarpia, Ivana Santi, Luigi Sciani, Gianni Scoccimarro, Eugenio Scopinaro, Angelo Giuseppe Semerano, Daniela Sferco, Anna Ersilia Sirtori, Angela Spandri, Bruno Spinelli, Fausto Stefanoni, Raffaele Taiana, Libero Tamagnini, Laura Tassi, Giorgio Tentori, Augusto Teodoro, Katerina Tinterova, Ampelio Tocchetti, Michela Todeschini, Lorenzo Trezza, Valter Valsecchi, Roberto Vanini, Claudio Felice Vercelloni, Anna Villella, Maria Viola, Pietro Vismara, Daniele Mario Zoboli, M. Montesano, S. Romi

Research output: Contribution to journalArticle

Abstract

Drug-resistant epilepsy (DRE) is defined by the International League Against Epilepsy as a failure of adequate trials of two tolerated, appropriately chosen, and used antiepileptic drugs to achieve sustained seizure freedom. Our aim was to calculate the following: (1) the prevalence of active epilepsy and DRE in a well-defined population of Northern Italy and (2) the proportion of incident cases developing DRE.The study population (146,506; year 2008) resided in the province of Lecco, Northern Italy. The medical records of 123 general practitioners were reviewed to identify patients with epilepsy, diagnosed by a neurologist during the period 2000-2008. The point prevalence of active epilepsy and DRE was calculated on December 31, 2008. A total of 747 prevalent patients with epilepsy, 684 patients with active epilepsy, and 342 incident cases were identified. The frequency of DRE was 15.6% (107/684) of all active epilepsies and 10.5% (36/342) of incident cases. The point prevalence was 0.73 per 1000. The standardized prevalence of DRE was 0.7 per 1000 (Italian population) and 0.8 per 1000 (world population).Our data indicate that 1/6 patients with active epilepsy in the general population has DRE, and 1/10 patients with newly diagnosed epilepsy will develop DRE within nine years from the diagnosis.

Original languageEnglish
Pages (from-to)30-37
Number of pages8
JournalEpilepsy and Behavior
Volume55
DOIs
Publication statusPublished - Feb 1 2016

Keywords

  • Drug resistance
  • Epilepsy
  • Medical practitioners
  • Prevalence

ASJC Scopus subject areas

  • Clinical Neurology
  • Behavioral Neuroscience
  • Neurology

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    Giussani, G., Canelli, V., Bianchi, E., Franchi, C., Nobili, A., Erba, G., Beghi, E., Agostoni, E., Airoldi, L., Basso, F., Carpanelli, M., Di Stefano, M., Magnoni, A., Martinelli, O., Rigamonti, A., Salmaggi, A., Stanzani, L., Volpe, C., Zanotta, N., ... Romi, S. (2016). A population-based study of active and drug-resistant epilepsies in Northern Italy. Epilepsy and Behavior, 55, 30-37. https://doi.org/10.1016/j.yebeh.2015.11.021