A possible anti-D autosensitization in A D (Rh(0)) negative patient

P. Strada; A. Rasore Quartino; P. G. Mori; A. M. Soldà; R. Adami; R. Haupt; G. Reali

A possible anti-D autosensitization in A D (Rh(0)) negative patient

P. Strada, A. Rasore Quartino, P. G. Mori, A. M. Soldà, R. Adami, R. Haupt, G. Reali

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

A case of a 14-year-old nulligravida girl affected with paroxysmal nocturnal hemoglobinuria (PNH) is reported. The patient's phenotype was A₁, rr, Le (a-b-), Kk. SHe was repeatedly transfused with only rr red blood cells, but she developed a strong and rapidly increasing anti-D (Rh(o)) antibody. It is suggested that the immunogenic stimulus could have been given by the D (Rh(o)) antigen present on the inner membrane surface of her rr red blood cells, exposed during severe and recurrent hemolytic crises. Laboratory evidence of this suggestion is presented.

Original language	English
Pages (from-to)	656-663
Number of pages	8
Journal	Haematologica
Volume	68
Issue number	5
Publication status	Published - 1983

ASJC Scopus subject areas

Hematology

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title = "A possible anti-D autosensitization in A D (Rh(0)) negative patient",

abstract = "A case of a 14-year-old nulligravida girl affected with paroxysmal nocturnal hemoglobinuria (PNH) is reported. The patient's phenotype was A1, rr, Le (a-b-), Kk. SHe was repeatedly transfused with only rr red blood cells, but she developed a strong and rapidly increasing anti-D (Rh(o)) antibody. It is suggested that the immunogenic stimulus could have been given by the D (Rh(o)) antigen present on the inner membrane surface of her rr red blood cells, exposed during severe and recurrent hemolytic crises. Laboratory evidence of this suggestion is presented.",

author = "P. Strada and {Rasore Quartino}, A. and Mori, {P. G.} and Sold{\`a}, {A. M.} and R. Adami and R. Haupt and G. Reali",

year = "1983",

language = "English",

volume = "68",

pages = "656--663",

journal = "Haematologica",

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T1 - A possible anti-D autosensitization in A D (Rh(0)) negative patient

AU - Strada, P.

AU - Rasore Quartino, A.

AU - Mori, P. G.

AU - Soldà, A. M.

AU - Adami, R.

AU - Haupt, R.

AU - Reali, G.

PY - 1983

Y1 - 1983

N2 - A case of a 14-year-old nulligravida girl affected with paroxysmal nocturnal hemoglobinuria (PNH) is reported. The patient's phenotype was A1, rr, Le (a-b-), Kk. SHe was repeatedly transfused with only rr red blood cells, but she developed a strong and rapidly increasing anti-D (Rh(o)) antibody. It is suggested that the immunogenic stimulus could have been given by the D (Rh(o)) antigen present on the inner membrane surface of her rr red blood cells, exposed during severe and recurrent hemolytic crises. Laboratory evidence of this suggestion is presented.

AB - A case of a 14-year-old nulligravida girl affected with paroxysmal nocturnal hemoglobinuria (PNH) is reported. The patient's phenotype was A1, rr, Le (a-b-), Kk. SHe was repeatedly transfused with only rr red blood cells, but she developed a strong and rapidly increasing anti-D (Rh(o)) antibody. It is suggested that the immunogenic stimulus could have been given by the D (Rh(o)) antigen present on the inner membrane surface of her rr red blood cells, exposed during severe and recurrent hemolytic crises. Laboratory evidence of this suggestion is presented.

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