A possible anti-D autosensitization in A D (Rh(0)) negative patient

P. Strada, A. Rasore Quartino, P. G. Mori, A. M. Soldà, R. Adami, R. Haupt, G. Reali

Research output: Contribution to journalArticlepeer-review


A case of a 14-year-old nulligravida girl affected with paroxysmal nocturnal hemoglobinuria (PNH) is reported. The patient's phenotype was A1, rr, Le (a-b-), Kk. SHe was repeatedly transfused with only rr red blood cells, but she developed a strong and rapidly increasing anti-D (Rh(o)) antibody. It is suggested that the immunogenic stimulus could have been given by the D (Rh(o)) antigen present on the inner membrane surface of her rr red blood cells, exposed during severe and recurrent hemolytic crises. Laboratory evidence of this suggestion is presented.

Original languageEnglish
Pages (from-to)656-663
Number of pages8
Issue number5
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Hematology

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