A possible association of Chlamydia pneumoniae infection and acute myocardial infarction in patients younger than 65 years of age

Francesco Blasi, Roberto Cosentini, Rita Raccanelli, Ferdinando M. Massari, Cristina Arosio, Paolo Tarsia, Luigi Allegra

Research output: Contribution to journalArticlepeer-review

Abstract

Study objectives: We conducted a retrospective study on patients with acute myocardial infarction (AMI) and evaluated the incidence and prevalence of Chlamydia pneumoniae infection. Methods: Sixty-one consecutive patients with AMI aged younger than 65 years were enrolled. Within 24 h of hospital admission, serum samples and pharyngeal swab specimens were obtained from all patients. In 49 of 61 patients, after a mean of 28 days from hospital admission, a second serum sample was drawn. A third serum sample was obtained in 23 of 61 patients. Serologic testing for Chlamydia pneumoniae was performed by a microimmunofluorescence test. We applied a nested-polymerase chain reaction for C pneumoniae DNA detection to pharyngeal swab specimens. Simultaneously, we performed a serologic study for C pueumoniae infection on 61 serum samples obtained from blood donors, matched for age, sex, and smoking habits. Results: Serologic test results for C pneumoniae were consistent with acute reinfection in 12 patients, with chronic infection in 23 patients, and results were negative in 26 patients with AMI. In 3 of 12 patients with acute reinfection pattern and in 3 of 23 patients with chronic infection pattern, C pneumoniae DNA was detected on pharyngeal swab specimens. A significantly higher prevalence of IgG liters was observed in patients with AMI (35/61) compared to blood donors (18/61) (p=0.003). Conclusion: Our data confirm the possible role of C pneumoniae infection in coronary heart disease and suggest that reinfection may tugger the onset of AMI.

Original languageEnglish
Pages (from-to)309-312
Number of pages4
JournalChest
Volume112
Issue number2
Publication statusPublished - 1997

Keywords

  • Acute myocardial infarction
  • Chlamydia pneumoniae
  • Polymerase chain reaction
  • Respiratory tract infections

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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