A possible growth factor role of IL-6 in neuroectodermal tumours

E. Candi, R. A. Knight, A. Spinedi, P. Guerrieri, G. Melino

Research output: Contribution to journalArticlepeer-review

Abstract

Preliminary data have shown that IL-6 may act as an autocrine growth factor to control proliferation. We further characterised the role of IL-6 in tumour growth as an autocrine/paracrine growth factor in neuroectodermal tumours. We evaluated the production and secretion of IL-6 by seven human melanoma, five neuroblastoma and one glioblastoma cell lines. Moreover, we determined their IL-6-dependent growth in serum free-medium or under minimal growth-supplement conditions: IL-6 dependent growth was observed in two non-IL-6 producing melanoma and in one neuroblastoma cell lines. In addition, expression of IL-6 mRNA and peptide was increased by retinoic acid. The data support the hypothesis that IL-6 contributes to neuroectodermal tumour growth, even though it shows a less potent effect than other reported growth factor such as IGF-II.

Original languageEnglish
Pages (from-to)115-122
Number of pages8
JournalJournal of Neuro-Oncology
Volume31
Issue number1-2
DOIs
Publication statusPublished - 1997

Keywords

  • IL-6
  • Melanoma
  • Neuroblastoma
  • Retinoic acid

ASJC Scopus subject areas

  • Clinical Neurology
  • Cancer Research
  • Oncology
  • Neuroscience(all)

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