A possible pathogenetic role of cationic proteins (CP) released by stored granulocytes in the development of pulmonary infiltrates after granulocyte transfusions

D. Campana, G. Camussi, L. Bergui, P. Vallauri, L. Tesio, C. Tetta, F. Caligaris-Cappio

Research output: Contribution to journalArticlepeer-review

Abstract

The cationic protein (CP) content of polymorphonuclear neutrophils (PMN) prepared for transfusion is depleted after storage. The supernatants from these PMN have in vitro a PMN aggregating activity which is abolished by the preabsorption with a specific rabbit anti-human PMN CP serum. Furthermore, when the supernatants stored for few hours were injected into New Zealand White rabbits, a marked sequestration of PMN took place in the lung microvascular bed. It is suggested that PMN storage per se can cause the release of intracellular mediators of possible pathogenetic importance in the development of the pulmonary infiltrates observed after PMN transfusions.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalScandinavian Journal of Haematology
Volume34
Issue number1
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Hematology

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