L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide?

Translated title of the contribution: A possible pathogenic role of Hp infection in rheumatoid arthritis

Patrizia Zentilin, Antonella Garnero, Laura Tessieri, Pietro Dulbecco, Bruno Seriolo, Salvatore Rovida, Vincenzo Savarino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this study we assessed the effect of Helicobacter pylori eradication in patients with established rheumatoid arthritis (RA) in order to show a possible pathogenetic role of the infection in this disease. Methods. We recruited 31 patients with variable RA activity. Of them, 15 were Hp-positive (12 F and 3 M, mean age 55±10.6 years) and 16 Hp-negative (13 F and 3 M, mean age 54.2±9.1 years) on the basis of the concomitant positive or negative findings of both CLO-test and histology performed on both antral and corpus biopsies. The infected group was treated and the bacterium was considered eradicated when both tests were negative a month after therapy. We have evaluated the disease activity at baseline and during a total follow-up period of 16 months with check-points every 4-months and compared clinical and laboratory findings between the Hp-negative and the eradicated groups. Both groups were being treated with NSAIDs and prednisolone (≤7.5 mg/die) or its equivalents. Results. Hp-eradicated RA patients showed a progressive improvement overtime (p=0.0009) of all clinical indices compared with baseline, while Hp-negative RA patients did not. At the 16-month checkpoint, the eradicated RA patients differed significantly (p

Original languageItalian
Pages (from-to)175-180
Number of pages6
JournalRecenti Progressi in Medicina
Volume91
Issue number4
Publication statusPublished - Apr 2000

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Rheumatoid Arthritis
Infection
Non-Steroidal Anti-Inflammatory Agents
Prednisolone
Helicobacter pylori
Histology
Bacteria
Biopsy
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Zentilin, P., Garnero, A., Tessieri, L., Dulbecco, P., Seriolo, B., Rovida, S., & Savarino, V. (2000). L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide? Recenti Progressi in Medicina, 91(4), 175-180.

L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide? / Zentilin, Patrizia; Garnero, Antonella; Tessieri, Laura; Dulbecco, Pietro; Seriolo, Bruno; Rovida, Salvatore; Savarino, Vincenzo.

In: Recenti Progressi in Medicina, Vol. 91, No. 4, 04.2000, p. 175-180.

Research output: Contribution to journalArticle

Zentilin, P, Garnero, A, Tessieri, L, Dulbecco, P, Seriolo, B, Rovida, S & Savarino, V 2000, 'L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide?', Recenti Progressi in Medicina, vol. 91, no. 4, pp. 175-180.
Zentilin P, Garnero A, Tessieri L, Dulbecco P, Seriolo B, Rovida S et al. L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide? Recenti Progressi in Medicina. 2000 Apr;91(4):175-180.
Zentilin, Patrizia ; Garnero, Antonella ; Tessieri, Laura ; Dulbecco, Pietro ; Seriolo, Bruno ; Rovida, Salvatore ; Savarino, Vincenzo. / L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide?. In: Recenti Progressi in Medicina. 2000 ; Vol. 91, No. 4. pp. 175-180.
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