L'infezione da helicobacter pylori può essere un fattore di rischio per la severità dell'artrite reumatoide?

Translated title of the contribution: A possible pathogenic role of Hp infection in rheumatoid arthritis

Patrizia Zentilin, Antonella Garnero, Laura Tessieri, Pietro Dulbecco, Bruno Seriolo, Salvatore Rovida, Vincenzo Savarino

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we assessed the effect of Helicobacter pylori eradication in patients with established rheumatoid arthritis (RA) in order to show a possible pathogenetic role of the infection in this disease. Methods. We recruited 31 patients with variable RA activity. Of them, 15 were Hp-positive (12 F and 3 M, mean age 55±10.6 years) and 16 Hp-negative (13 F and 3 M, mean age 54.2±9.1 years) on the basis of the concomitant positive or negative findings of both CLO-test and histology performed on both antral and corpus biopsies. The infected group was treated and the bacterium was considered eradicated when both tests were negative a month after therapy. We have evaluated the disease activity at baseline and during a total follow-up period of 16 months with check-points every 4-months and compared clinical and laboratory findings between the Hp-negative and the eradicated groups. Both groups were being treated with NSAIDs and prednisolone (≤7.5 mg/die) or its equivalents. Results. Hp-eradicated RA patients showed a progressive improvement overtime (p=0.0009) of all clinical indices compared with baseline, while Hp-negative RA patients did not. At the 16-month checkpoint, the eradicated RA patients differed significantly (p

Translated title of the contributionA possible pathogenic role of Hp infection in rheumatoid arthritis
Original languageItalian
Pages (from-to)175-180
Number of pages6
JournalRecenti Progressi in Medicina
Volume91
Issue number4
Publication statusPublished - Apr 2000

ASJC Scopus subject areas

  • Medicine(all)

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