A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet

Francesco Russo, Guglielmina Chimienti, Caterina Clemente, Carla Ferreri, Antonella Orlando, Giuseppe Riezzo

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.

METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.

RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).

CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.

Original languageEnglish
Pages (from-to)807-818
Number of pages12
JournalEuropean Journal of Nutrition
Volume56
Issue number2
DOIs
Publication statusPublished - Mar 2017

Fingerprint

Gluten-Free Diet
Ghrelin
Docosahexaenoic Acids
Brain-Derived Neurotrophic Factor
Celiac Disease
Leptin
Quality of Life
Dietetics
Nerve Growth Factors
Serum
Abdomen
Healthy Volunteers
Erythrocytes
Cell Membrane
Hormones
Psychology

Keywords

  • Adult
  • Alleles
  • Amino Acid Substitution
  • Brain-Derived Neurotrophic Factor
  • Case-Control Studies
  • Celiac Disease
  • Diarrhea
  • Diet, Gluten-Free
  • Docosahexaenoic Acids
  • Erythrocyte Membrane
  • Female
  • Follow-Up Studies
  • Gene Frequency
  • Genetic Association Studies
  • Ghrelin
  • Heterozygote
  • Humans
  • Italy
  • Leptin
  • Male
  • Polymorphism, Single Nucleotide
  • Prospective Studies
  • Quality of Life
  • Stress, Psychological
  • Journal Article

Cite this

@article{0328ffa567d24494b365ea6febe8dd1f,
title = "A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet",
abstract = "PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.",
keywords = "Adult, Alleles, Amino Acid Substitution, Brain-Derived Neurotrophic Factor, Case-Control Studies, Celiac Disease, Diarrhea, Diet, Gluten-Free, Docosahexaenoic Acids, Erythrocyte Membrane, Female, Follow-Up Studies, Gene Frequency, Genetic Association Studies, Ghrelin, Heterozygote, Humans, Italy, Leptin, Male, Polymorphism, Single Nucleotide, Prospective Studies, Quality of Life, Stress, Psychological, Journal Article",
author = "Francesco Russo and Guglielmina Chimienti and Caterina Clemente and Carla Ferreri and Antonella Orlando and Giuseppe Riezzo",
year = "2017",
month = "3",
doi = "10.1007/s00394-015-1128-2",
language = "English",
volume = "56",
pages = "807--818",
journal = "European Journal of Nutrition",
issn = "1436-6207",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

TY - JOUR

T1 - A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet

AU - Russo, Francesco

AU - Chimienti, Guglielmina

AU - Clemente, Caterina

AU - Ferreri, Carla

AU - Orlando, Antonella

AU - Riezzo, Giuseppe

PY - 2017/3

Y1 - 2017/3

N2 - PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.

AB - PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.

KW - Adult

KW - Alleles

KW - Amino Acid Substitution

KW - Brain-Derived Neurotrophic Factor

KW - Case-Control Studies

KW - Celiac Disease

KW - Diarrhea

KW - Diet, Gluten-Free

KW - Docosahexaenoic Acids

KW - Erythrocyte Membrane

KW - Female

KW - Follow-Up Studies

KW - Gene Frequency

KW - Genetic Association Studies

KW - Ghrelin

KW - Heterozygote

KW - Humans

KW - Italy

KW - Leptin

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Quality of Life

KW - Stress, Psychological

KW - Journal Article

U2 - 10.1007/s00394-015-1128-2

DO - 10.1007/s00394-015-1128-2

M3 - Article

VL - 56

SP - 807

EP - 818

JO - European Journal of Nutrition

JF - European Journal of Nutrition

SN - 1436-6207

IS - 2

ER -