Abstract
PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.
METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.
RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).
CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.
| Original language | English |
|---|---|
| Pages (from-to) | 807-818 |
| Number of pages | 12 |
| Journal | European Journal of Nutrition |
| Volume | 56 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Mar 2017 |
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Keywords
- Adult
- Alleles
- Amino Acid Substitution
- Brain-Derived Neurotrophic Factor
- Case-Control Studies
- Celiac Disease
- Diarrhea
- Diet, Gluten-Free
- Docosahexaenoic Acids
- Erythrocyte Membrane
- Female
- Follow-Up Studies
- Gene Frequency
- Genetic Association Studies
- Ghrelin
- Heterozygote
- Humans
- Italy
- Leptin
- Male
- Polymorphism, Single Nucleotide
- Prospective Studies
- Quality of Life
- Stress, Psychological
- Journal Article
Cite this
A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet. / Russo, Francesco; Chimienti, Guglielmina; Clemente, Caterina; Ferreri, Carla; Orlando, Antonella; Riezzo, Giuseppe.
In: European Journal of Nutrition, Vol. 56, No. 2, 03.2017, p. 807-818.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A possible role for ghrelin, leptin, brain-derived neurotrophic factor and docosahexaenoic acid in reducing the quality of life of coeliac disease patients following a gluten-free diet
AU - Russo, Francesco
AU - Chimienti, Guglielmina
AU - Clemente, Caterina
AU - Ferreri, Carla
AU - Orlando, Antonella
AU - Riezzo, Giuseppe
PY - 2017/3
Y1 - 2017/3
N2 - PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.
AB - PURPOSE: A gluten-free diet (GFD) has been reported to negatively impact the quality of life (QoL) of coeliac disease (CD) patients. The gut-brain axis hormones ghrelin and leptin, with the brain-derived neurotrophic factor (BDNF), may affect QoL of CD patients undergoing GFD. Our aims were to evaluate whether: (a) the circulating concentrations of leptin, ghrelin and BDNF in CD patients were different from those in healthy subjects; (b) GFD might induce changes in their levels; (c) BDNF Val66Met polymorphism variability might affect BDNF levels; and (d) serum BDNF levels were related to dietary docosahexaenoic acid (DHA) as a neurotrophin modulator.METHODS: Nineteen adult coeliac patients and 21 healthy controls were included. A QoL questionnaire was administered, and serum concentrations of ghrelin, leptin, BDNF and red blood cell membrane DHA levels were determined at the enrolment and after 1 year of GFD. BDNF Val66Met polymorphism was analysed.RESULTS: Results from the questionnaire indicated a decline in QoL after GFD. Ghrelin and leptin levels were not significantly different between groups. BDNF levels were significantly (p = 0.0213) lower in patients after GFD (22.0 ± 2.4 ng/ml) compared to controls (31.2 ± 2.2 ng/ml) and patients at diagnosis (25.0 ± 2.5 ng/ml). BDNF levels correlated with DHA levels (p = 0.008, r = 0.341) and the questionnaire total score (p = 0.041, r = 0.334).CONCLUSIONS: Ghrelin and leptin seem to not be associated with changes in QoL of patients undergoing dietetic treatment. In contrast, a link between BDNF reduction and the vulnerability of CD patients to psychological distress could be proposed, with DHA representing a possible intermediate.
KW - Adult
KW - Alleles
KW - Amino Acid Substitution
KW - Brain-Derived Neurotrophic Factor
KW - Case-Control Studies
KW - Celiac Disease
KW - Diarrhea
KW - Diet, Gluten-Free
KW - Docosahexaenoic Acids
KW - Erythrocyte Membrane
KW - Female
KW - Follow-Up Studies
KW - Gene Frequency
KW - Genetic Association Studies
KW - Ghrelin
KW - Heterozygote
KW - Humans
KW - Italy
KW - Leptin
KW - Male
KW - Polymorphism, Single Nucleotide
KW - Prospective Studies
KW - Quality of Life
KW - Stress, Psychological
KW - Journal Article
U2 - 10.1007/s00394-015-1128-2
DO - 10.1007/s00394-015-1128-2
M3 - Article
VL - 56
SP - 807
EP - 818
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
IS - 2
ER -