A potent and selective inhibition of parainfluenza 1 (Sendai) virus by new 6-oxiranyl-, 6-methyloxiranyluracils, and 4(3H)-pyrimidinone derivatives

Raffaele Saladino, Maria Chiara Danti, Enrico Mincione, Claudia Crestini, Anna Teresa Palamara, Patrizia Savini, Stefano Marini, Maurizio Botta

Research output: Contribution to journalArticlepeer-review

Abstract

Several new 6-oxiranyl-, 6-methyloxiranyluracils, and pyrimidinone derivatives, synthesized by the lithiation-alkylation sequence of 1,3,6- trimethyluracil, 1,3-dimethyl-6-chloromethyluracil, and 2-alkoxy-6-methyl- 4(3H)-pyrimidinones, showed a potent and selective antiviral activity against the parainfluenza 1 (Sendai) virus replication.

Original languageEnglish
Pages (from-to)1833-1838
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume8
Issue number14
DOIs
Publication statusPublished - Jul 21 1998

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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