A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza

Nicasio Mancini, Laura Solforosi, Nicola Clementi, Donata De Marco, Massimo Clementi, Roberto Burioni

Research output: Contribution to journalArticle

Abstract

The role of humoral response in the effective control of infection by influenza viruses is well known, but the protection is usually limited to the infecting or vaccinating isolate and to few related strains. Recent studies have evidenced the existence of B-cell epitopes broadly conserved among different influenza subtypes recognized by monoclonal antibodies endowed with unprecedented broad activity. In this review, all major monoclonal antibodies directed against different influenza virus proteins are reported and their potential in the design of new anti-influenza prophylactic or therapeutic strategies is discussed.

Original languageEnglish
Pages (from-to)15-26
Number of pages12
JournalAntiviral Research
Volume92
Issue number1
DOIs
Publication statusPublished - Oct 2011

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Keywords

  • Influenza viruses
  • Monoclonal antibodies
  • Universal epitopes

ASJC Scopus subject areas

  • Virology
  • Pharmacology

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