A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.)

Arianna Di Napoli, D. Remotti, C. Agostinelli, M. R. Ambrosio, S. Ascani, A. Carbone, F. Facchetti, S. Lazzi, L. Leoncini, M. Lucioni, D. Novero, S. Pileri, M. Ponzoni, E. Sabattini, C. Tripodo, A. Zamò, M. Paulli, L. Ruco

Research output: Contribution to journalArticle

Abstract

© 2019, The Author(s). An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
Original languageEnglish
JournalVirchows Archiv
DOIs
Publication statusPublished - Jan 1 2019

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B-Cell Lymphoma
Cytogenetics
Therapeutics

Keywords

  • Diagnosis
  • DLBCL
  • Double hit
  • FISH
  • HGBL
  • MYC

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A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.). / Di Napoli, Arianna; Remotti, D.; Agostinelli, C.; Ambrosio, M. R.; Ascani, S.; Carbone, A.; Facchetti, F.; Lazzi, S.; Leoncini, L.; Lucioni, M.; Novero, D.; Pileri, S.; Ponzoni, M.; Sabattini, E.; Tripodo, C.; Zamò, A.; Paulli, M.; Ruco, L.

In: Virchows Archiv, 01.01.2019.

Research output: Contribution to journalArticle

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AU - Remotti, D.

AU - Agostinelli, C.

AU - Ambrosio, M. R.

AU - Ascani, S.

AU - Carbone, A.

AU - Facchetti, F.

AU - Lazzi, S.

AU - Leoncini, L.

AU - Lucioni, M.

AU - Novero, D.

AU - Pileri, S.

AU - Ponzoni, M.

AU - Sabattini, E.

AU - Tripodo, C.

AU - Zamò, A.

AU - Paulli, M.

AU - Ruco, L.

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