Abstract
| Original language | English |
|---|---|
| Journal | Virchows Archiv |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Diagnosis
- DLBCL
- Double hit
- FISH
- HGBL
- MYC
Cite this
A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.). / Di Napoli, Arianna; Remotti, D.; Agostinelli, C.; Ambrosio, M. R.; Ascani, S.; Carbone, A.; Facchetti, F.; Lazzi, S.; Leoncini, L.; Lucioni, M.; Novero, D.; Pileri, S.; Ponzoni, M.; Sabattini, E.; Tripodo, C.; Zamò, A.; Paulli, M.; Ruco, L.
In: Virchows Archiv, 01.01.2019.Research output: Contribution to journal › Article
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TY - JOUR
T1 - A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.)
AU - Di Napoli, Arianna
AU - Remotti, D.
AU - Agostinelli, C.
AU - Ambrosio, M. R.
AU - Ascani, S.
AU - Carbone, A.
AU - Facchetti, F.
AU - Lazzi, S.
AU - Leoncini, L.
AU - Lucioni, M.
AU - Novero, D.
AU - Pileri, S.
AU - Ponzoni, M.
AU - Sabattini, E.
AU - Tripodo, C.
AU - Zamò, A.
AU - Paulli, M.
AU - Ruco, L.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - © 2019, The Author(s). An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
AB - © 2019, The Author(s). An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.
KW - Diagnosis
KW - DLBCL
KW - Double hit
KW - FISH
KW - HGBL
KW - MYC
UR - http://www.scopus.com/inward/record.url?scp=85070186582&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070186582&partnerID=8YFLogxK
U2 - 10.1007/s00428-019-02637-2
DO - 10.1007/s00428-019-02637-2
M3 - Article
AN - SCOPUS:85070186582
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
ER -