A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit : A position paper from the Italian Group of Haematopathology (G.I.E.)

Arianna Di Napoli, D Remotti, C Agostinelli, M R Ambrosio, S Ascani, A Carbone, F Facchetti, S Lazzi, L Leoncini, M Lucioni, D Novero, S Pileri, M Ponzoni, E Sabattini, C Tripodo, A Zamò, M Paulli, L Ruco

Research output: Contribution to journalArticle


An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient.

Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalVirchows Archiv - A Pathological Anatomy and Histopathology
Issue number4
Publication statusPublished - Oct 2019



  • Algorithms
  • Humans
  • Immunophenotyping/methods
  • In Situ Hybridization, Fluorescence/methods
  • Lymphoma, B-Cell/diagnosis

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