TY - JOUR
T1 - A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.)
T2 - Virchows Archiv
AU - Di Napoli, A
AU - Remotti, D
AU - Agostinelli, C
AU - Ambrosio, MR
AU - Ascani, S
AU - Carbone, A
AU - Facchetti, F
AU - Lazzi, S
AU - Leoncini, L
AU - Lucioni, M
AU - Novero, D
AU - Pileri, S
AU - Ponzoni, M
AU - Sabattini, E
AU - Tripodo, C
AU - Zamò, A
AU - Paulli, M
AU - Ruco, L
PY - 2019
Y1 - 2019
N2 - An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient. © 2019, The Author(s).
AB - An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient. © 2019, The Author(s).
U2 - 10.1007/s00428-019-02637-2
DO - 10.1007/s00428-019-02637-2
M3 - Article
VL - 475
SP - 513
EP - 518
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 4
ER -