A practical algorithmic approach to mature aggressive B cell lymphoma diagnosis in the double/triple hit era: selecting cases, matching clinical benefit: A position paper from the Italian Group of Haematopathology (G.I.E.): Virchows Archiv

A Di Napoli, D Remotti, C Agostinelli, MR Ambrosio, S Ascani, A Carbone, F Facchetti, S Lazzi, L Leoncini, M Lucioni, D Novero, S Pileri, M Ponzoni, E Sabattini, C Tripodo, A Zamò, M Paulli, L Ruco

Research output: Contribution to journalArticlepeer-review

Abstract

An accurate diagnosis of clinically distinct subgroups of aggressive mature B cell lymphomas is crucial for the choice of proper treatment. Presently, precise recognition of these disorders relies on the combination of morphological, immunophenotypical, and cytogenetic/molecular features. The diagnostic workup in such situations implies the application of costly and time-consuming analyses, which are not always required, since an intensified treatment option is reasonably reserved to fit patients. The Italian Group of Haematopathology proposes herein a practical algorithm for the diagnosis of aggressive mature B cell lymphomas based on a stepwise approach, aimed to select cases deserving molecular analysis, in order to optimize time and resources still assuring the optimal management for any patient. © 2019, The Author(s).
Original languageEnglish
Pages (from-to)513-518
Number of pages6
JournalVirchows Archiv - A Pathological Anatomy and Histopathology
Volume475
Issue number4
DOIs
Publication statusPublished - 2019

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