A practical management of children with antibiotic allergy

Elisabetta Calamelli, Carlo Caffarelli, Fabrizio Franceschini, Francesca Saretta, Fabio Cardinale, Roberto Bernardini, Lucia Liotti, Francesca Mori, Giuseppe Crisafulli, Silvia Caimmi, Paolo Bottau

Research output: Contribution to journalReview articlepeer-review


About 10% of the parents reported that their children are allergic to one drug and the betalactam antibiotics are the most frequently suspected. Even if most of the adverse events following antibiotic prescriptions to children are considered allergic, after a full allergy work-up only a few of the suspected reactions are confirmed. For this reason, many children are incorrectly labelled as “allergic” and this represents an important challenge for the choice of the antibiotic therapy in these “labelled” children, who are frequently improperly deprived of narrow-spectrum antibiotics because considered as allergic. When an allergic reaction is suspected a precise diagnosis and a choice of a safe and effective alternative is essential for the future antibiotic option. In the light of this, the main aim of this paper is to try to provide a practical approach to managing the individuals who have reported adverse reactions to antibiotics. (www.actabiomedica.it).

Original languageEnglish
Pages (from-to)11-19
Number of pages9
JournalActa Biomedica
Publication statusPublished - Jan 1 2019


  • Antibiotic allergy
  • Basophil activation test
  • Betalactam
  • Children
  • Drug adverse reaction
  • Drug provocation test
  • Hypersensitivity reactions
  • Skin test
  • Specific IgE

ASJC Scopus subject areas

  • Medicine(all)


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