A predictive model of varicella-zoster vires infection after autologous peripheral blood progenitor cell transplantation

M. Offidani, L. Corvatta, A. Olivieri, A. Mele, M. Brunori, M. Montanari, S. Rupoli, P. Scalari, P. Leoni

Research output: Contribution to journalArticle

Abstract

Varicella-zoster virus (VZV) frequently causes severe infections in patients who have undergone bone marrow transplantation. The frequency of, characteristics of, and risk factors for this infection were studied in 164 patients undergoing autologous peripheral blood progenitor cell transplantation (PBPCT). Twenty-six patients (15.8%) developed VZV infection, and the actuarial risk was 10% at 1 year. No patient had visceral dissemination or died because of VZV, although one-third of the patients developed postherpetic neuralgia. By multivariate analysis, a CD4+ lymphocyte count of + lymphocyte count of + and CD8+ lymphocytes are at high risk of VZV infection. These patients should be considered as candidates for preventive therapy, but whether for antiviral therapy or vaccination remains to be investigated.

Original languageEnglish
Pages (from-to)1414-1422
Number of pages9
JournalClinical Infectious Diseases
Volume32
Issue number10
DOIs
Publication statusPublished - May 15 2001

ASJC Scopus subject areas

  • Immunology

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