A predictor of unfavourable outcome in neutropenic paediatric patients presenting with fever of unknown origin

Michaela Semeraro, Caroline Thomée, Estelle Rolland, Marie Cecile Le Deley, David Rosselini, Frederic Troalen, Loredana Amoroso, Marie Dubrel, Olivier Hartmann

Research output: Contribution to journalArticlepeer-review

Abstract

Background. No sensitive, specific marker able to discriminate favourable or unfavourable outcome of fever of unknown origin (FUO) at diagnosis has been identified. Procalcitonin, a recently assessed infection marker, may be useful in predicting the outcome of FUO. Methods. We conducted a prospective study examining the following variables: age 0.5-22 years; solid tumour diagnosis; chemotherapy-related grade-4 febrile neutropenia (FN). A complete clinical, bacteriological and biological evaluation was performed at hospital admission (H0). Other investigations depended on clinical status. FUO was considered to be of unfavourable outcome if the fever was persistent or re-appeared at day 3 (or later), or if secondary clinical or microbiological infection occurred. To validate the results of the analysis the data set was randomly split into a training set and a validation set. Results. Out of 172 episodes of FN, 136 episodes were classified as FUO (80%). Seventy-two (53%) were included in this study. PCT values were significantly higher in episodes of unfavourable outcome (P

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalPediatric Blood and Cancer
Volume54
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • Aplasia
  • Cancer
  • Children
  • FUO
  • Procalcitonin

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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