Abstract
Background: The systemic autoinflammatory disorders (SAID) share many clinical manifestations, albeit with variable patterns, intensity and frequency. A common definition of disease activity would be rational and useful in the management of these lifelong diseases. Moreover, standardised disease activity scores are required for the assessment of new therapies in constant development. The aim of this study was to develop preliminary activity scores for familial Mediterranean fever, mevalonate kinase deficiency, tumour necrosis factor receptor-1-associated periodic syndrome and cryopyrin-associated periodic syndromes (CAPS). Methods: The study was conducted using two well-recognised consensus formation methods:the Delphi technique and the nominal group technique. The results from a two-step survey and data from parent/patient interviews were used as preliminary data to develop the agenda for a consensus conference to build a provisional scoring system. Results: 24 of 65 experts in SAID from 20 countries answered the web questionnaire and 16 attended the consensus conference. There was consensus agreement to develop separate activity scores for each disease but with a common format based on patient diaries. Fever and disease-specific clinical variables were scored according to their severity. A final score was generated by summing the score of all the variables divided by the number of days over which the diary was completed. Scores varied from 0 to 16 (0-13 in CAPS). These scores were developed for the purpose of clinical studies but could be used in clinical practice. Conclusion: Using widely recognised consensus formation techniques, preliminary scores were obtained to measure disease activity in four main SAID. Further prospective validation study of this instrument will follow.
| Original language | English |
|---|---|
| Pages (from-to) | 309-314 |
| Number of pages | 6 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 70 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 2011 |
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ASJC Scopus subject areas
- Rheumatology
- Immunology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Allergy
Cite this
A preliminary score for the assessment of disease activity in hereditary recurrent fevers : Results from the AIDAI (Auto-Inflammatory Diseases Activity Index) consensus conference. / Piram, Maryam; Frenkel, Joost; Gattorno, Marco; Ozen, Seza; Lachmann, Helen J.; Goldbach-Mansky, Raphaela; Hentgen, Véronique; Neven, Bénédicte; Stojanovic, Katia Stankovic; Simon, Anna; Kuemmerle-Deschner, Jasmin; Hoffman, Hal; Stojanov, Silvia; Duquesne, Agnès; Pillet, Pascal; Martini, Alberto; Pouchot, Jacques; Koné-Paut, Isabelle.
In: Annals of the Rheumatic Diseases, Vol. 70, No. 2, 02.2011, p. 309-314.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A preliminary score for the assessment of disease activity in hereditary recurrent fevers
T2 - Results from the AIDAI (Auto-Inflammatory Diseases Activity Index) consensus conference
AU - Piram, Maryam
AU - Frenkel, Joost
AU - Gattorno, Marco
AU - Ozen, Seza
AU - Lachmann, Helen J.
AU - Goldbach-Mansky, Raphaela
AU - Hentgen, Véronique
AU - Neven, Bénédicte
AU - Stojanovic, Katia Stankovic
AU - Simon, Anna
AU - Kuemmerle-Deschner, Jasmin
AU - Hoffman, Hal
AU - Stojanov, Silvia
AU - Duquesne, Agnès
AU - Pillet, Pascal
AU - Martini, Alberto
AU - Pouchot, Jacques
AU - Koné-Paut, Isabelle
PY - 2011/2
Y1 - 2011/2
N2 - Background: The systemic autoinflammatory disorders (SAID) share many clinical manifestations, albeit with variable patterns, intensity and frequency. A common definition of disease activity would be rational and useful in the management of these lifelong diseases. Moreover, standardised disease activity scores are required for the assessment of new therapies in constant development. The aim of this study was to develop preliminary activity scores for familial Mediterranean fever, mevalonate kinase deficiency, tumour necrosis factor receptor-1-associated periodic syndrome and cryopyrin-associated periodic syndromes (CAPS). Methods: The study was conducted using two well-recognised consensus formation methods:the Delphi technique and the nominal group technique. The results from a two-step survey and data from parent/patient interviews were used as preliminary data to develop the agenda for a consensus conference to build a provisional scoring system. Results: 24 of 65 experts in SAID from 20 countries answered the web questionnaire and 16 attended the consensus conference. There was consensus agreement to develop separate activity scores for each disease but with a common format based on patient diaries. Fever and disease-specific clinical variables were scored according to their severity. A final score was generated by summing the score of all the variables divided by the number of days over which the diary was completed. Scores varied from 0 to 16 (0-13 in CAPS). These scores were developed for the purpose of clinical studies but could be used in clinical practice. Conclusion: Using widely recognised consensus formation techniques, preliminary scores were obtained to measure disease activity in four main SAID. Further prospective validation study of this instrument will follow.
AB - Background: The systemic autoinflammatory disorders (SAID) share many clinical manifestations, albeit with variable patterns, intensity and frequency. A common definition of disease activity would be rational and useful in the management of these lifelong diseases. Moreover, standardised disease activity scores are required for the assessment of new therapies in constant development. The aim of this study was to develop preliminary activity scores for familial Mediterranean fever, mevalonate kinase deficiency, tumour necrosis factor receptor-1-associated periodic syndrome and cryopyrin-associated periodic syndromes (CAPS). Methods: The study was conducted using two well-recognised consensus formation methods:the Delphi technique and the nominal group technique. The results from a two-step survey and data from parent/patient interviews were used as preliminary data to develop the agenda for a consensus conference to build a provisional scoring system. Results: 24 of 65 experts in SAID from 20 countries answered the web questionnaire and 16 attended the consensus conference. There was consensus agreement to develop separate activity scores for each disease but with a common format based on patient diaries. Fever and disease-specific clinical variables were scored according to their severity. A final score was generated by summing the score of all the variables divided by the number of days over which the diary was completed. Scores varied from 0 to 16 (0-13 in CAPS). These scores were developed for the purpose of clinical studies but could be used in clinical practice. Conclusion: Using widely recognised consensus formation techniques, preliminary scores were obtained to measure disease activity in four main SAID. Further prospective validation study of this instrument will follow.
UR - http://www.scopus.com/inward/record.url?scp=78751688718&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751688718&partnerID=8YFLogxK
U2 - 10.1136/ard.2010.132613
DO - 10.1136/ard.2010.132613
M3 - Article
C2 - 21081528
AN - SCOPUS:78751688718
VL - 70
SP - 309
EP - 314
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 2
ER -