A preliminary study of magnetization transfer and diffusion tensor MRI of multiple sclerosis patients with fatigue

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Abstract

To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue) MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.

Original languageEnglish
Pages (from-to)535-537
Number of pages3
JournalJournal of Neurology
Volume249
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Diffusion tensor imaging
  • Fatigue
  • Magnetic resonance imaging
  • Magnetization transfer imaging
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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