A preliminary study of magnetization transfer and diffusion tensor MRI of multiple sclerosis patients with fatigue

M. Codella; Maria Assunta Rocca; Bruno Colombo; Paolo Rossi; Giancarlo Comi; Massimo Filippi

doi:10.1007/s004150200060

A preliminary study of magnetization transfer and diffusion tensor MRI of multiple sclerosis patients with fatigue

M. Codella, Maria Assunta Rocca, Bruno Colombo, Paolo Rossi, Giancarlo Comi, Massimo Filippi

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue) MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.

Original language	English
Pages (from-to)	535-537
Number of pages	3
Journal	Journal of Neurology
Volume	249
Issue number	5
DOIs	https://doi.org/10.1007/s004150200060
Publication status	Published - 2002

Keywords

Diffusion tensor imaging
Fatigue
Magnetic resonance imaging
Magnetization transfer imaging
Multiple sclerosis

ASJC Scopus subject areas

Clinical Neurology
Neurology

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10.1007/s004150200060

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abstract = "To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue) MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.",

keywords = "Diffusion tensor imaging, Fatigue, Magnetic resonance imaging, Magnetization transfer imaging, Multiple sclerosis",

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AU - Codella, M.

AU - Assunta Rocca, Maria

AU - Colombo, Bruno

AU - Rossi, Paolo

AU - Comi, Giancarlo

AU - Filippi, Massimo

PY - 2002

Y1 - 2002

N2 - To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue) MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.

AB - To investigate whether multiple sclerosis (MS) tissue damage is associated with the presence and severity of fatigue, we obtained magnetization transfer (MT) and diffusion tensor (DT) magnetic resonance imaging from 28 patients with MS (14 with and 14 without fatigue) MT ratio and mean diffusivity did not differ between fatigued and non-fatigued MS patients. No correlation was found between Fatigue Severity Scale scores and any of the MT and DT MRI-derived quantities. This preliminary study suggests that the severity of overall MS pathology in the brain seems not to be a critical factor contributing to the development of fatigue in MS.

KW - Diffusion tensor imaging

KW - Fatigue

KW - Magnetic resonance imaging

KW - Magnetization transfer imaging

KW - Multiple sclerosis

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A preliminary study of magnetization transfer and diffusion tensor MRI of multiple sclerosis patients with fatigue

Abstract

Keywords

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