A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America

S. M. Pueschel, C. Romano, P. Failla, C. Barone, R. Pettinato, A. Castellano Chiodo, D. L. Plumari

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.

Original languageEnglish
Pages (from-to)953-956
Number of pages4
JournalActa Paediatrica, International Journal of Paediatrics
Volume88
Issue number9
DOIs
Publication statusPublished - 1999

Fingerprint

Celiac Disease
Down Syndrome
Cross-Sectional Studies
Antibodies
Immunoglobulin G
Chromosome Disorders
Immunoglobulin A
Esophagus
Atrophy
Haplorhini
Fluorescent Antibody Technique
Biopsy

Keywords

  • Antiendomysium antibodies
  • Celiac disease
  • Down syndrome
  • IgG and IgA antigliadin antibodies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America. / Pueschel, S. M.; Romano, C.; Failla, P.; Barone, C.; Pettinato, R.; Castellano Chiodo, A.; Plumari, D. L.

In: Acta Paediatrica, International Journal of Paediatrics, Vol. 88, No. 9, 1999, p. 953-956.

Research output: Contribution to journalArticle

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