A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America

S. M. Pueschel; C. Romano; P. Failla; C. Barone; R. Pettinato; A. Castellano Chiodo; D. L. Plumari

doi:10.1080/08035259950168432

A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America

S. M. Pueschel, C. Romano, P. Failla, C. Barone, R. Pettinato, A. Castellano Chiodo, D. L. Plumari

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Abstract

In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.

Original language	English
Pages (from-to)	953-956
Number of pages	4
Journal	Acta Paediatrica, International Journal of Paediatrics
Volume	88
Issue number	9
DOIs	https://doi.org/10.1080/08035259950168432
Publication status	Published - 1999

Keywords

Antiendomysium antibodies
Celiac disease
Down syndrome
IgG and IgA antigliadin antibodies

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1080/08035259950168432

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title = "A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America",

abstract = "In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.",

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AU - Pueschel, S. M.

AU - Romano, C.

AU - Failla, P.

AU - Barone, C.

AU - Pettinato, R.

AU - Castellano Chiodo, A.

AU - Plumari, D. L.

PY - 1999

Y1 - 1999

N2 - In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.

AB - In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.

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KW - Celiac disease

KW - Down syndrome

KW - IgG and IgA antigliadin antibodies

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A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America

Abstract

Keywords

ASJC Scopus subject areas

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