Abstract
In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.
| Original language | English |
|---|---|
| Pages (from-to) | 953-956 |
| Number of pages | 4 |
| Journal | Acta Paediatrica, International Journal of Paediatrics |
| Volume | 88 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 1999 |
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Keywords
- Antiendomysium antibodies
- Celiac disease
- Down syndrome
- IgG and IgA antigliadin antibodies
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America. / Pueschel, S. M.; Romano, C.; Failla, P.; Barone, C.; Pettinato, R.; Castellano Chiodo, A.; Plumari, D. L.
In: Acta Paediatrica, International Journal of Paediatrics, Vol. 88, No. 9, 1999, p. 953-956.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America
AU - Pueschel, S. M.
AU - Romano, C.
AU - Failla, P.
AU - Barone, C.
AU - Pettinato, R.
AU - Castellano Chiodo, A.
AU - Plumari, D. L.
PY - 1999
Y1 - 1999
N2 - In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.
AB - In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG AGA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant-villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down-syndrome have celiac disease.
KW - Antiendomysium antibodies
KW - Celiac disease
KW - Down syndrome
KW - IgG and IgA antigliadin antibodies
UR - http://www.scopus.com/inward/record.url?scp=0032832763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032832763&partnerID=8YFLogxK
U2 - 10.1080/08035259950168432
DO - 10.1080/08035259950168432
M3 - Article
C2 - 10519335
AN - SCOPUS:0032832763
VL - 88
SP - 953
EP - 956
JO - Acta Paediatrica, International Journal of Paediatrics
JF - Acta Paediatrica, International Journal of Paediatrics
SN - 0803-5253
IS - 9
ER -