A project by the SIDeMaST Immunopathology Group on cutaneous vasculitis

M. Papini, P. Quaglino, M. La Placa, A. V. Marzano

Research output: Contribution to journalArticle

Abstract

Vasculitides are a challenge to the clinician, in terms of both diagnosis and therapy. Multiple classification systems have been implemented and the numerous classification schemes reflect the complexity of establishing a simple classification that could be functional for daily care. Although vasculitis classification has become increasingly elaborated, some areas remain ill defined. Some forms of vasculitis are still difficult to assign to a specific disease entity. Generally accepted operational criteria are available for many vasculitides, but for some entities there are no effective criteria. Moreover, diagnostic criteria for vasculitis with sufficient strength and/or confidence that can be universally accepted are not yet available. The need for diagnostic criteria validated and agreed upon is particularly relevant in the context of cutaneous vasculitis. The project of the SIDeMaST Italian Group of Immunopathology on cutaneous vasculitis is a national prospective observational study designed to develop and validate diagnostic criteria and to improve and validate classification criteria for cutaneous small vessel vasculitis also known as leukocytoclastic vasculitis (CLV). Primary objective of the study will also be that of developing the CUtaneous VAsculitis Severity Index (CUVASI). Secondary objectives of the project will be: 1) definition of the etiological agents that are most frequently associated with CLV; 2) search for possible correlations between causative agent and peculiar clinical and/or histopathological aspects; 3) evaluation of immunofluorescence pattern observed in this specific group of primitive cutaneous vasculitis in order to characterize the diagnostic sensitivity and specificity of this technique; 4) identification of a set of clinical investigations and laboratory tests to be performed for a correct CLV assessment. Actually 15 Italian dermatological clinics are contributing to the project and anticipated recruiting >100 patients with CLV. A pilot retrospective study to assess the feasibility of the project is going to be launched and if its results are positive then the prospective study will be started and it promises to be a unique opportunity to evaluate a large database on CLV in Italian population.

Original languageEnglish
Pages (from-to)165-167
Number of pages3
JournalGiornale Italiano di Dermatologia e Venereologia
Volume150
Issue number2
Publication statusPublished - Apr 1 2015

Fingerprint

Vasculitis
Skin
Prospective Studies
Observational Studies
Fluorescent Antibody Technique
Retrospective Studies
Databases
Sensitivity and Specificity

Keywords

  • Cutaneous
  • Diagnosis
  • Leukocytoclastic
  • Severity of ilness index
  • Vasculitis

ASJC Scopus subject areas

  • Dermatology
  • Medicine(all)

Cite this

A project by the SIDeMaST Immunopathology Group on cutaneous vasculitis. / Papini, M.; Quaglino, P.; La Placa, M.; Marzano, A. V.

In: Giornale Italiano di Dermatologia e Venereologia, Vol. 150, No. 2, 01.04.2015, p. 165-167.

Research output: Contribution to journalArticle

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