A proposal of simple calculation (ERI calculator) to predict the early response to TNF-α blockers therapy in rheumatoid arthritis

Laura Bazzichi, Paolo Rossi, Camillo Giacomelli, Francesca De Feo, Francesca Bobbio-Pallavicini, Alessandra Rossi, Chiara Baldini, Arianna Consensi, Marica Doveri, Claudia Bonino, Maurizio Mazzantini, Alessandra Della Rossa, Carlomaurizio Montecucco, Stefano Bombardieri

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Increasing evidence has been accumulated for treating rheumatoid arthritis (RA) with TNF-α blocking agents. The formulation and definition of an early indicator of patient's reactivity during therapy may be extremely simplified by a mathematical model of clinical response. We analyzed the most significant clinical and laboratory parameters of response of 35 homogeneous patients (30 women, 5 men mean age ± SD: 52.31 ± 12.30 years) treated with adalimumab 40 mg every 2 weeks associated with methotrexate (MTX) 10-15 mg/week and with a stable dosage of steroids for 30 weeks. The over time trend of the studied parameters showed a linear response, which has allowed the realization of a simple mathematical model. The formula derived from this mathematical model was then applied and therefore validated in a group of 121 patients previously treated with several anti-TNF-alpha agents for at least 6 months. We drafted a mathematical model (early response indicator, ERI) that, by using a simple calculation, allows us to identify a high percentage of responder patients after only 2 weeks of treatment. ERI identified a high percentage (88%) of patients responding after only 2 weeks, as was confirmed at weeks 30; the use of ERI calculation after 6 weeks increases the proportion of responding patients to 92% with a percentage of false negatives of only 12%. ERI could be a useful tool to early differentiate the responder from the non-responder patients.

Original languageEnglish
Pages (from-to)349-356
Number of pages8
JournalRheumatology International
Volume32
Issue number2
DOIs
Publication statusPublished - Feb 2012

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Rheumatoid Arthritis
Theoretical Models
Therapeutics
Methotrexate
Tumor Necrosis Factor-alpha
Steroids

Keywords

  • Mathematical model
  • Rheumatoid Arthritis
  • TNF-alpha blocking agents

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

A proposal of simple calculation (ERI calculator) to predict the early response to TNF-α blockers therapy in rheumatoid arthritis. / Bazzichi, Laura; Rossi, Paolo; Giacomelli, Camillo; De Feo, Francesca; Bobbio-Pallavicini, Francesca; Rossi, Alessandra; Baldini, Chiara; Consensi, Arianna; Doveri, Marica; Bonino, Claudia; Mazzantini, Maurizio; Della Rossa, Alessandra; Montecucco, Carlomaurizio; Bombardieri, Stefano.

In: Rheumatology International, Vol. 32, No. 2, 02.2012, p. 349-356.

Research output: Contribution to journalArticle

Bazzichi, L, Rossi, P, Giacomelli, C, De Feo, F, Bobbio-Pallavicini, F, Rossi, A, Baldini, C, Consensi, A, Doveri, M, Bonino, C, Mazzantini, M, Della Rossa, A, Montecucco, C & Bombardieri, S 2012, 'A proposal of simple calculation (ERI calculator) to predict the early response to TNF-α blockers therapy in rheumatoid arthritis', Rheumatology International, vol. 32, no. 2, pp. 349-356. https://doi.org/10.1007/s00296-010-1619-7
Bazzichi, Laura ; Rossi, Paolo ; Giacomelli, Camillo ; De Feo, Francesca ; Bobbio-Pallavicini, Francesca ; Rossi, Alessandra ; Baldini, Chiara ; Consensi, Arianna ; Doveri, Marica ; Bonino, Claudia ; Mazzantini, Maurizio ; Della Rossa, Alessandra ; Montecucco, Carlomaurizio ; Bombardieri, Stefano. / A proposal of simple calculation (ERI calculator) to predict the early response to TNF-α blockers therapy in rheumatoid arthritis. In: Rheumatology International. 2012 ; Vol. 32, No. 2. pp. 349-356.
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