A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma: The record1 italian project

Riccardo Schiavina, Sergio Serni, Andrea Mari, Alessandro Antonelli, Riccardo Bertolo, Giampaolo Bianchi, Eugenio Brunocilla, Marco Borghesi, Marco Carini, Nicola Longo, Giuseppe Martorana, Vincenzo Mirone, Giuseppe Morgia, Francesco Porpiglia, Bernardo Rocco, Bruno Rovereto, Claudio Simeone, Mario Sodano, Carlo Terrone, Vincenzo FicarraAndrea Minervini

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background The purpose of this study was to evaluate the predictors of positive margins in one of the largest available prospective multi-institutional studies. Patients and Methods We evaluated all patients who underwent NSS for radiologically diagnosed kidney tumors between January 2009 and December 2012 at 19 urological Italian centers (Registry of Conservative Renal Surgery [RECORd] project). Preoperative and anthropometric data, comorbidities, intraoperative and postoperative outcomes, and histological findings were analyzed. The negative and PSMs were compared according to the clinical and surgical variables. Multivariable logistic regression models were applied to analyze predictors of PSMs. Results Eight hundred consecutive patients were evaluated. Seven hundred sixty-one (95.1%) and 39 patients (4.9%) achieved negative and PSMs, respectively. Patients with PSMs were significantly older compared with those with negative margins (median age: 66.6 vs. 61.8 years, respectively; P =.001). A higher incidence of PSMs was observed when NSS was performed for renal masses located in the upper pole (P =.001). A lower rate of PSMs was found in patients treated with simple enucleation rather than standard PN (1.6% vs. 7.4%, respectively; P

Original languageEnglish
Pages (from-to)165-170
Number of pages6
JournalClinical Genitourinary Cancer
Volume13
Issue number2
DOIs
Publication statusPublished - Apr 1 2015

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Nephrons
Renal Cell Carcinoma
Kidney
Logistic Models
Registries
Margins of Excision
Comorbidity
Incidence
Neoplasms

Keywords

  • Partial nephrectomy
  • Positive margin
  • Predictors
  • Renal cancer
  • Simple tumor enucleation

ASJC Scopus subject areas

  • Oncology
  • Urology
  • Medicine(all)

Cite this

A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma : The record1 italian project. / Schiavina, Riccardo; Serni, Sergio; Mari, Andrea; Antonelli, Alessandro; Bertolo, Riccardo; Bianchi, Giampaolo; Brunocilla, Eugenio; Borghesi, Marco; Carini, Marco; Longo, Nicola; Martorana, Giuseppe; Mirone, Vincenzo; Morgia, Giuseppe; Porpiglia, Francesco; Rocco, Bernardo; Rovereto, Bruno; Simeone, Claudio; Sodano, Mario; Terrone, Carlo; Ficarra, Vincenzo; Minervini, Andrea.

In: Clinical Genitourinary Cancer, Vol. 13, No. 2, 01.04.2015, p. 165-170.

Research output: Contribution to journalArticle

Schiavina, R, Serni, S, Mari, A, Antonelli, A, Bertolo, R, Bianchi, G, Brunocilla, E, Borghesi, M, Carini, M, Longo, N, Martorana, G, Mirone, V, Morgia, G, Porpiglia, F, Rocco, B, Rovereto, B, Simeone, C, Sodano, M, Terrone, C, Ficarra, V & Minervini, A 2015, 'A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma: The record1 italian project', Clinical Genitourinary Cancer, vol. 13, no. 2, pp. 165-170. https://doi.org/10.1016/j.clgc.2014.08.008
Schiavina, Riccardo ; Serni, Sergio ; Mari, Andrea ; Antonelli, Alessandro ; Bertolo, Riccardo ; Bianchi, Giampaolo ; Brunocilla, Eugenio ; Borghesi, Marco ; Carini, Marco ; Longo, Nicola ; Martorana, Giuseppe ; Mirone, Vincenzo ; Morgia, Giuseppe ; Porpiglia, Francesco ; Rocco, Bernardo ; Rovereto, Bruno ; Simeone, Claudio ; Sodano, Mario ; Terrone, Carlo ; Ficarra, Vincenzo ; Minervini, Andrea. / A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma : The record1 italian project. In: Clinical Genitourinary Cancer. 2015 ; Vol. 13, No. 2. pp. 165-170.
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T1 - A prospective, multicenter evaluation of predictive factors for positive surgical margins after nephron-sparing surgery for renal cell carcinoma

T2 - The record1 italian project

AU - Schiavina, Riccardo

AU - Serni, Sergio

AU - Mari, Andrea

AU - Antonelli, Alessandro

AU - Bertolo, Riccardo

AU - Bianchi, Giampaolo

AU - Brunocilla, Eugenio

AU - Borghesi, Marco

AU - Carini, Marco

AU - Longo, Nicola

AU - Martorana, Giuseppe

AU - Mirone, Vincenzo

AU - Morgia, Giuseppe

AU - Porpiglia, Francesco

AU - Rocco, Bernardo

AU - Rovereto, Bruno

AU - Simeone, Claudio

AU - Sodano, Mario

AU - Terrone, Carlo

AU - Ficarra, Vincenzo

AU - Minervini, Andrea

PY - 2015/4/1

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N2 - Background The purpose of this study was to evaluate the predictors of positive margins in one of the largest available prospective multi-institutional studies. Patients and Methods We evaluated all patients who underwent NSS for radiologically diagnosed kidney tumors between January 2009 and December 2012 at 19 urological Italian centers (Registry of Conservative Renal Surgery [RECORd] project). Preoperative and anthropometric data, comorbidities, intraoperative and postoperative outcomes, and histological findings were analyzed. The negative and PSMs were compared according to the clinical and surgical variables. Multivariable logistic regression models were applied to analyze predictors of PSMs. Results Eight hundred consecutive patients were evaluated. Seven hundred sixty-one (95.1%) and 39 patients (4.9%) achieved negative and PSMs, respectively. Patients with PSMs were significantly older compared with those with negative margins (median age: 66.6 vs. 61.8 years, respectively; P =.001). A higher incidence of PSMs was observed when NSS was performed for renal masses located in the upper pole (P =.001). A lower rate of PSMs was found in patients treated with simple enucleation rather than standard PN (1.6% vs. 7.4%, respectively; P

AB - Background The purpose of this study was to evaluate the predictors of positive margins in one of the largest available prospective multi-institutional studies. Patients and Methods We evaluated all patients who underwent NSS for radiologically diagnosed kidney tumors between January 2009 and December 2012 at 19 urological Italian centers (Registry of Conservative Renal Surgery [RECORd] project). Preoperative and anthropometric data, comorbidities, intraoperative and postoperative outcomes, and histological findings were analyzed. The negative and PSMs were compared according to the clinical and surgical variables. Multivariable logistic regression models were applied to analyze predictors of PSMs. Results Eight hundred consecutive patients were evaluated. Seven hundred sixty-one (95.1%) and 39 patients (4.9%) achieved negative and PSMs, respectively. Patients with PSMs were significantly older compared with those with negative margins (median age: 66.6 vs. 61.8 years, respectively; P =.001). A higher incidence of PSMs was observed when NSS was performed for renal masses located in the upper pole (P =.001). A lower rate of PSMs was found in patients treated with simple enucleation rather than standard PN (1.6% vs. 7.4%, respectively; P

KW - Partial nephrectomy

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KW - Predictors

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