TY - JOUR
T1 - A prospective multicenter randomized clinical trial of autogenous bone versus β-tricalcium phosphate graft alone for bilateral sinus elevation
T2 - Histologic and histomorphometric evaluation
AU - Szabó, György
AU - Huys, Luc
AU - Coulthard, Paul
AU - Maiorana, Carlo
AU - Garagiola, Umberto
AU - Barabás, József
AU - Németh, Zsolt
AU - Hrabák, Károly
AU - Suba, Zsuzsanna
PY - 2005/5
Y1 - 2005/5
N2 - Purpose: Two different graft materials, β-tricalcium phosphate (Cerasorb) and autogenous bone, were used in the same patient. The objective was to determine whether donor site morbidity could be avoided by using pure-phase β-tricalcium phosphate (Cerasorb). Materials and Methods: Bilateral sinus grafting was performed on 20 selected patients; Cerasorb was used on the experimental side, and autogenous bone was used on the control side. In each patient, one side was randomly designated the experimental side. In 10 of the 20 patients, the maxilla reconstruction included sinus grafting and onlay bone grafting. Implants were placed 6 months after the procedure. In addition to routine panoramic radiographs, in 10 of the 20 patients, 2- and 3-dimensional computerized tomographic examinations were performed pre- and postoperatively and after implantation. Eighty bone biopsy specimens were taken at the time of implant placement. Results: Histologically and histomorphometrically, there was no significant difference between the experimental and control grafts in terms of the quantity and rate of ossification. For each histologic sample, the total surface area, the surface area that consisted of bone, and the surface area that consisted of graft material were measured in mm2, and bone and graft material were analyzed as percentages of the total. The mean percentage bone areas were 36.47% ± 6.9% and 38.34% ± 7.4%, respectively; the difference was not significant (P = .25). Discussion and Conclusion: Comparisons with other studies reveal that β-tricalcium phosphate (Cerasorb) is a satisfactory graft material, even without autogenous bone.
AB - Purpose: Two different graft materials, β-tricalcium phosphate (Cerasorb) and autogenous bone, were used in the same patient. The objective was to determine whether donor site morbidity could be avoided by using pure-phase β-tricalcium phosphate (Cerasorb). Materials and Methods: Bilateral sinus grafting was performed on 20 selected patients; Cerasorb was used on the experimental side, and autogenous bone was used on the control side. In each patient, one side was randomly designated the experimental side. In 10 of the 20 patients, the maxilla reconstruction included sinus grafting and onlay bone grafting. Implants were placed 6 months after the procedure. In addition to routine panoramic radiographs, in 10 of the 20 patients, 2- and 3-dimensional computerized tomographic examinations were performed pre- and postoperatively and after implantation. Eighty bone biopsy specimens were taken at the time of implant placement. Results: Histologically and histomorphometrically, there was no significant difference between the experimental and control grafts in terms of the quantity and rate of ossification. For each histologic sample, the total surface area, the surface area that consisted of bone, and the surface area that consisted of graft material were measured in mm2, and bone and graft material were analyzed as percentages of the total. The mean percentage bone areas were 36.47% ± 6.9% and 38.34% ± 7.4%, respectively; the difference was not significant (P = .25). Discussion and Conclusion: Comparisons with other studies reveal that β-tricalcium phosphate (Cerasorb) is a satisfactory graft material, even without autogenous bone.
KW - β-tricalcium phosphate
KW - Autogenous bone
KW - Donor site morbidity
KW - Sinus elevation
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M3 - Article
C2 - 15973948
AN - SCOPUS:21344471923
VL - 20
SP - 371
EP - 381
JO - International Journal of Oral and Maxillofacial Implants
JF - International Journal of Oral and Maxillofacial Implants
SN - 0882-2786
IS - 3
ER -