Abstract
Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.
| Original language | English |
|---|---|
| Pages (from-to) | 49-54 |
| Number of pages | 6 |
| Journal | Digestive and Liver Disease |
| Volume | 48 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 1 2016 |
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Keywords
- 22-Gauge needle
- 25-Gauge needle
- Endoscopic ultrasound
- Fine needle aspiration
ASJC Scopus subject areas
- Gastroenterology
- Hepatology
Cite this
A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses. / Carrara, Silvia; Anderloni, Andrea; Jovani, Manol; Di Tommaso, Luca; Rahal, Daoud; Hassan, Cesare; Ridola, Lorenzo; Federico, Davide; Loriga, Alessandra; Repici, Alessandro.
In: Digestive and Liver Disease, Vol. 48, No. 1, 01.01.2016, p. 49-54.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses
AU - Carrara, Silvia
AU - Anderloni, Andrea
AU - Jovani, Manol
AU - Di Tommaso, Luca
AU - Rahal, Daoud
AU - Hassan, Cesare
AU - Ridola, Lorenzo
AU - Federico, Davide
AU - Loriga, Alessandra
AU - Repici, Alessandro
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.
AB - Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.
KW - 22-Gauge needle
KW - 25-Gauge needle
KW - Endoscopic ultrasound
KW - Fine needle aspiration
UR - http://www.scopus.com/inward/record.url?scp=84955651527&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84955651527&partnerID=8YFLogxK
U2 - 10.1016/j.dld.2015.09.017
DO - 10.1016/j.dld.2015.09.017
M3 - Article
VL - 48
SP - 49
EP - 54
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 1
ER -