A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses

Silvia Carrara, Andrea Anderloni, Manol Jovani, Luca Di Tommaso, Daoud Rahal, Cesare Hassan, Lorenzo Ridola, Davide Federico, Alessandra Loriga, Alessandro Repici

Research output: Contribution to journalArticle

Abstract

Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalDigestive and Liver Disease
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Keywords

  • 22-Gauge needle
  • 25-Gauge needle
  • Endoscopic ultrasound
  • Fine needle aspiration

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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