A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses

Silvia Carrara, Andrea Anderloni, Manol Jovani, Luca Di Tommaso, Daoud Rahal, Cesare Hassan, Lorenzo Ridola, Davide Federico, Alessandra Loriga, Alessandro Repici

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.

Original languageEnglish
Pages (from-to)49-54
Number of pages6
JournalDigestive and Liver Disease
Volume48
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Endoscopic Ultrasound-Guided Fine Needle Aspiration
Needles
Prospective Studies
Fine Needle Biopsy
Randomized Controlled Trials
Lymph Nodes

Keywords

  • 22-Gauge needle
  • 25-Gauge needle
  • Endoscopic ultrasound
  • Fine needle aspiration

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses. / Carrara, Silvia; Anderloni, Andrea; Jovani, Manol; Di Tommaso, Luca; Rahal, Daoud; Hassan, Cesare; Ridola, Lorenzo; Federico, Davide; Loriga, Alessandra; Repici, Alessandro.

In: Digestive and Liver Disease, Vol. 48, No. 1, 01.01.2016, p. 49-54.

Research output: Contribution to journalArticle

@article{a4b0a54ca2444b8aa621a2348a8dbbcc,
title = "A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses",
abstract = "Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3{\%} of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81{\%} vs. 68{\%}; p=0.09). Crossover was required in 14 (19{\%}) and 12 (17{\%}) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74{\%} before crossover to 90{\%} after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8{\%} vs. 86.1{\%}; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90{\%}.",
keywords = "22-Gauge needle, 25-Gauge needle, Endoscopic ultrasound, Fine needle aspiration",
author = "Silvia Carrara and Andrea Anderloni and Manol Jovani and {Di Tommaso}, Luca and Daoud Rahal and Cesare Hassan and Lorenzo Ridola and Davide Federico and Alessandra Loriga and Alessandro Repici",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.dld.2015.09.017",
language = "English",
volume = "48",
pages = "49--54",
journal = "Digestive and Liver Disease",
issn = "1590-8658",
publisher = "Elsevier B.V.",
number = "1",

}

TY - JOUR

T1 - A prospective randomized study comparing 25-G and 22-G needles of a new platform for endoscopic ultrasound-guided fine needle aspiration of solid masses

AU - Carrara, Silvia

AU - Anderloni, Andrea

AU - Jovani, Manol

AU - Di Tommaso, Luca

AU - Rahal, Daoud

AU - Hassan, Cesare

AU - Ridola, Lorenzo

AU - Federico, Davide

AU - Loriga, Alessandra

AU - Repici, Alessandro

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.

AB - Background: A new needle platform for endoscopic ultrasound-guided fine-needle aspiration biopsy has been developed that allows interchangeability of all needle sizes. Aims: To prospectively compare the efficacy of the new 25-G needles and 22-G needles for obtaining an adequate aspirate of solid masses. Methods: Randomized controlled trial of 144 patients referred for endoscopic ultrasound-guided fine-needle aspiration of solid pancreatic masses, intraparietal tumours, or lymph-nodes, randomized to the 25-G or 22-G needle arms. Results: An adequate specimen was obtained from 74.3% of cases. The sample tended to be more adequate in the 25-G compared to the 22-G group (81% vs. 68%; p=0.09). Crossover was required in 14 (19%) and 12 (17%) cases in the 22-G and in the 25-G groups, respectively (p= 0.7). The overall rate of adequacy improved from 74% before crossover to 90% after crossover (p<0.01). When comparing the two groups after crossover, the rate of obtaining adequate samples was significantly higher in the 25-G arm than in the 22-G arm (95.8% vs. 86.1%; p= 0.03). Conclusions: The 25-G needle was superior to the 22-G needle for endoscopic ultrasound-guided fine-needle aspiration biopsy. The adequacy and diagnostic accuracy improved after crossover, reaching 90%.

KW - 22-Gauge needle

KW - 25-Gauge needle

KW - Endoscopic ultrasound

KW - Fine needle aspiration

UR - http://www.scopus.com/inward/record.url?scp=84955651527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955651527&partnerID=8YFLogxK

U2 - 10.1016/j.dld.2015.09.017

DO - 10.1016/j.dld.2015.09.017

M3 - Article

VL - 48

SP - 49

EP - 54

JO - Digestive and Liver Disease

JF - Digestive and Liver Disease

SN - 1590-8658

IS - 1

ER -