Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim

E. Bottacchi; E. Carenini; E. Boati; D. Porazzi; G. Grampa; R. Guerrini; A. Ferrari; A. Belmonte; G. Coppola; R. Scarpello; P. G. Zagnoni; G. De Luca; G. Zaccara; A. Borgheresi; F. Viani; M. Viri; R. Mutani; P. Naldi; M. Gianelli; P. P. Benetello; A. Tartara; C. Galimberti; R. Manni; I. Sartori; L. Murri; R. Galli; C. Gneri; S. Ruggeri; L. Bramante; G. Gobbi; G. Bertani; A. Pini; P. Benedetti; M. Brinciotti; F. Giannotti; S. Mazza; M. L. Vaccario; E. Moro; F. Monaco; R. Rocchi; S. Carapelli; E. Morgando; R. Cremo; M. De Mattei; D. Moscato; I. Sacerdote; S. Gentile; [No Value] Zola; M. Nobili; L. Vivalda; D. Leotta; L. G. Bongiovanni; M. D. Benedetti; A. Nappo

Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim

Translated title of the contribution: A prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation

E. Bottacchi, E. Carenini, E. Boati, D. Porazzi, G. Grampa, R. Guerrini, A. Ferrari, A. Belmonte, G. Coppola, R. Scarpello, P. G. Zagnoni, G. De Luca, G. Zaccara, A. Borgheresi, F. Viani, M. Viri, R. Mutani, P. Naldi, M. Gianelli, P. P. BenetelloA. Tartara, C. Galimberti, R. Manni, I. Sartori, L. Murri, R. Galli, C. Gneri, S. Ruggeri, L. Bramante, G. Gobbi, G. Bertani, A. Pini, P. Benedetti, M. Brinciotti, F. Giannotti, S. Mazza, M. L. Vaccario, E. Moro, F. Monaco, R. Rocchi, S. Carapelli, E. Morgando, R. Cremo, M. De Mattei, D. Moscato, I. Sacerdote, S. Gentile, [No Value] Zola, M. Nobili, L. Vivalda, D. Leotta, L. G. Bongiovanni, M. D. Benedetti, A. Nappo

Research output: Contribution to journal › Article › peer-review

Abstract

To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.

Translated title of the contribution	A prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation
Original language	Italian
Pages (from-to)	171-173
Number of pages	3
Journal	Bollettino - Lega Italiana contro l'Epilessia
Issue number	95-96
Publication status	Published - 1996

ASJC Scopus subject areas

Clinical Neurology

Cite this

Bottacchi, E., Carenini, E., Boati, E., Porazzi, D., Grampa, G., Guerrini, R., Ferrari, A., Belmonte, A., Coppola, G., Scarpello, R., Zagnoni, P. G., De Luca, G., Zaccara, G., Borgheresi, A., Viani, F., Viri, M., Mutani, R., Naldi, P., Gianelli, M., ... Nappo, A. (1996). Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim. Bollettino - Lega Italiana contro l'Epilessia, (95-96), 171-173.

Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi : Valutazione ad interim. / Bottacchi, E.; Carenini, E.; Boati, E. et al.

In: Bollettino - Lega Italiana contro l'Epilessia, No. 95-96, 1996, p. 171-173.

Research output: Contribution to journal › Article › peer-review

Bottacchi, E, Carenini, E, Boati, E, Porazzi, D, Grampa, G, Guerrini, R, Ferrari, A, Belmonte, A, Coppola, G, Scarpello, R, Zagnoni, PG, De Luca, G, Zaccara, G, Borgheresi, A, Viani, F, Viri, M, Mutani, R, Naldi, P, Gianelli, M, Benetello, PP, Tartara, A, Galimberti, C , Manni, R, Sartori, I, Murri, L, Galli, R, Gneri, C, Ruggeri, S, Bramante, L, Gobbi, G, Bertani, G, Pini, A, Benedetti, P, Brinciotti, M, Giannotti, F, Mazza, S, Vaccario, ML, Moro, E, Monaco, F, Rocchi, R, Carapelli, S, Morgando, E, Cremo, R, De Mattei, M, Moscato, D, Sacerdote, I, Gentile, S, Zola, NV, Nobili, M, Vivalda, L, Leotta, D, Bongiovanni, LG, Benedetti, MD & Nappo, A 1996, 'Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim', Bollettino - Lega Italiana contro l'Epilessia, no. 95-96, pp. 171-173.

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title = "Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim",

abstract = "To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.",

keywords = "Antiepileptic drugs, Randomized clinical trial, Therapeutic drug monitoring",

author = "E. Bottacchi and E. Carenini and E. Boati and D. Porazzi and G. Grampa and R. Guerrini and A. Ferrari and A. Belmonte and G. Coppola and R. Scarpello and Zagnoni, {P. G.} and {De Luca}, G. and G. Zaccara and A. Borgheresi and F. Viani and M. Viri and R. Mutani and P. Naldi and M. Gianelli and Benetello, {P. P.} and A. Tartara and C. Galimberti and R. Manni and I. Sartori and L. Murri and R. Galli and C. Gneri and S. Ruggeri and L. Bramante and G. Gobbi and G. Bertani and A. Pini and P. Benedetti and M. Brinciotti and F. Giannotti and S. Mazza and Vaccario, {M. L.} and E. Moro and F. Monaco and R. Rocchi and S. Carapelli and E. Morgando and R. Cremo and {De Mattei}, M. and D. Moscato and I. Sacerdote and S. Gentile and Zola, {[No Value]} and M. Nobili and L. Vivalda and D. Leotta and Bongiovanni, {L. G.} and Benedetti, {M. D.} and A. Nappo",

year = "1996",

language = "Italian",

pages = "171--173",

journal = "Bollettino - Lega Italiana contro l'Epilessia",

issn = "0394-560X",

publisher = "Lega Italiana contro l'Epilessia",

number = "95-96",

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TY - JOUR

T1 - Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi

T2 - Valutazione ad interim

AU - Bottacchi, E.

AU - Carenini, E.

AU - Boati, E.

AU - Porazzi, D.

AU - Grampa, G.

AU - Guerrini, R.

AU - Ferrari, A.

AU - Belmonte, A.

AU - Coppola, G.

AU - Scarpello, R.

AU - Zagnoni, P. G.

AU - De Luca, G.

AU - Zaccara, G.

AU - Borgheresi, A.

AU - Viani, F.

AU - Viri, M.

AU - Mutani, R.

AU - Naldi, P.

AU - Gianelli, M.

AU - Benetello, P. P.

AU - Tartara, A.

AU - Galimberti, C.

AU - Manni, R.

AU - Sartori, I.

AU - Murri, L.

AU - Galli, R.

AU - Gneri, C.

AU - Ruggeri, S.

AU - Bramante, L.

AU - Gobbi, G.

AU - Bertani, G.

AU - Pini, A.

AU - Benedetti, P.

AU - Brinciotti, M.

AU - Giannotti, F.

AU - Mazza, S.

AU - Vaccario, M. L.

AU - Moro, E.

AU - Monaco, F.

AU - Rocchi, R.

AU - Carapelli, S.

AU - Morgando, E.

AU - Cremo, R.

AU - De Mattei, M.

AU - Moscato, D.

AU - Sacerdote, I.

AU - Gentile, S.

AU - Zola, [No Value]

AU - Nobili, M.

AU - Vivalda, L.

AU - Leotta, D.

AU - Bongiovanni, L. G.

AU - Benedetti, M. D.

AU - Nappo, A.

PY - 1996

Y1 - 1996

N2 - To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.

AB - To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.

KW - Antiepileptic drugs

KW - Randomized clinical trial

KW - Therapeutic drug monitoring

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UR - http://www.scopus.com/inward/citedby.url?scp=0030377611&partnerID=8YFLogxK

M3 - Articolo

AN - SCOPUS:0030377611

SP - 171

EP - 173

JO - Bollettino - Lega Italiana contro l'Epilessia

JF - Bollettino - Lega Italiana contro l'Epilessia

SN - 0394-560X

IS - 95-96

ER -

Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim

Abstract

ASJC Scopus subject areas

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