Abstract
To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.
| Translated title of the contribution | A prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation |
|---|---|
| Original language | Italian |
| Pages (from-to) | 171-173 |
| Number of pages | 3 |
| Journal | Bollettino - Lega Italiana contro l'Epilessia |
| Issue number | 95-96 |
| Publication status | Published - 1996 |
ASJC Scopus subject areas
- Clinical Neurology
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Cite this
Bottacchi, E., Carenini, E., Boati, E., Porazzi, D., Grampa, G., Guerrini, R., Ferrari, A., Belmonte, A., Coppola, G., Scarpello, R., Zagnoni, P. G., De Luca, G., Zaccara, G., Borgheresi, A., Viani, F., Viri, M., Mutani, R., Naldi, P., Gianelli, M., ... Nappo, A. (1996). Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim. Bollettino - Lega Italiana contro l'Epilessia, (95-96), 171-173.