Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim

Translated title of the contribution: A prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation

E. Bottacchi, E. Carenini, E. Boati, D. Porazzi, G. Grampa, R. Guerrini, A. Ferrari, A. Belmonte, G. Coppola, R. Scarpello, P. G. Zagnoni, G. De Luca, G. Zaccara, A. Borgheresi, F. Viani, M. Viri, R. Mutani, P. Naldi, M. Gianelli, P. P. BenetelloA. Tartara, C. Galimberti, R. Manni, I. Sartori, L. Murri, R. Galli, C. Gneri, S. Ruggeri, L. Bramante, G. Gobbi, G. Bertani, A. Pini, P. Benedetti, M. Brinciotti, F. Giannotti, S. Mazza, M. L. Vaccario, E. Moro, F. Monaco, R. Rocchi, S. Carapelli, E. Morgando, R. Cremo, M. De Mattei, D. Moscato, I. Sacerdote, S. Gentile, [No Value] Zola, M. Nobili, L. Vivalda, D. Leotta, L. G. Bongiovanni, M. D. Benedetti, A. Nappo

Research output: Contribution to journalArticle

Abstract

To assess the impact of therapeutic drug monitoring on clinical outcome, 171 patients with recently diagnosed epilepsy were randomized to two groups. In one group, drug dosage was individualized according to clinical response, whereas in the other group treatment was aimed at obtaining serum drug concentrations within the optimal range. At a preliminary analysis after a mean follow-up of 14 months, no major differences in seizure control or prevalence of adverse events emerged between the two groups. In both groups, more than 60% of patients remained seizure free after initiation of therapy.

Translated title of the contributionA prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation
Original languageItalian
Pages (from-to)171-173
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number95-96
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Clinical Neurology

Fingerprint Dive into the research topics of 'A prospective randomized study on the clinical impact of therapeutic drug monitoring in patients with newly diagnosed epilepsy: Interim evaluation'. Together they form a unique fingerprint.

  • Cite this

    Bottacchi, E., Carenini, E., Boati, E., Porazzi, D., Grampa, G., Guerrini, R., Ferrari, A., Belmonte, A., Coppola, G., Scarpello, R., Zagnoni, P. G., De Luca, G., Zaccara, G., Borgheresi, A., Viani, F., Viri, M., Mutani, R., Naldi, P., Gianelli, M., ... Nappo, A. (1996). Studio prospettico randomizzato sull'impatto clinico del monitoraggio terapeutico dei farmaci antiepilettici in pazienti con epilessia di recente diagnosi: Valutazione ad interim. Bollettino - Lega Italiana contro l'Epilessia, (95-96), 171-173.