A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network

Viviana Moschese, S. Graziani, M. A. Avanzini, R. Carsetti, M. Marconi, M. La Rocca, L. Chini, C. Pignata, A. R. Soresina, R. Consolini, G. Bossi, A. Trizzino, S. Martino, F. Cardinale, P. Bertolini, G. L. Marseglia, M. Zecca, S. Di Cesare, I. Quinti, R. RondelliM. C. Pietrogrande, P. Rossi, A. Plebani

Research output: Contribution to journalArticlepeer-review

Abstract

Transient hypogammaglobulinemia of infancy (THI) is a heterogenous disorder characterized by reduced serum IgG levels in early infancy. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children with an initial diagnosis of THI in correlation to natural outcome, and to assess predictive laboratory parameters of clinical evolution for this disorder. We prospectively analysed clinical and immunological characteristics of 77 THI children at initial diagnosis and of 57 patients at follow-up. Memory B cell subsets and in vitro immunoglobulin production were evaluated. Seventy patients (91%) showed clinical symptoms. Patients suffered from infections (91%), allergies (47%) and autoimmune disease (4%). During follow-up 41/57 children (72%) normalized IgG values, mostly within 24 months of age (p

Original languageEnglish
Pages (from-to)343-352
Number of pages10
JournalInternational Journal of Immunopathology and Pharmacology
Volume21
Issue number2
Publication statusPublished - Apr 2008

Keywords

  • In vitro immunoglobulin production
  • Memory B cell subsets
  • Primary immunodeficiency
  • Transient hypogammaglobulinemia of infancy

ASJC Scopus subject areas

  • Pharmacology

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