A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network

Viviana Moschese; S. Graziani; M. A. Avanzini; R. Carsetti; M. Marconi; M. La Rocca; L. Chini; C. Pignata; A. R. Soresina; R. Consolini; G. Bossi; A. Trizzino; S. Martino; F. Cardinale; P. Bertolini; G. L. Marseglia; M. Zecca; S. Di Cesare; I. Quinti; R. Rondelli; M. C. Pietrogrande; P. Rossi; A. Plebani

A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network

Viviana Moschese, S. Graziani, M. A. Avanzini, R. Carsetti, M. Marconi, M. La Rocca, L. Chini, C. Pignata, A. R. Soresina, R. Consolini, G. Bossi, A. Trizzino, S. Martino, F. Cardinale, P. Bertolini, G. L. Marseglia, M. Zecca, S. Di Cesare, I. Quinti, R. RondelliM. C. Pietrogrande, P. Rossi, A. Plebani

Research output: Contribution to journal › Article › peer-review

Abstract

Transient hypogammaglobulinemia of infancy (THI) is a heterogenous disorder characterized by reduced serum IgG levels in early infancy. A putative diagnosis is initially made after exclusion of other causes of hypogammaglobulinemia while a definitive diagnosis of THI can only be made a posteriori in patients with normalization of IgG levels. The aim of this study is to characterize clinical and immunological features of children with an initial diagnosis of THI in correlation to natural outcome, and to assess predictive laboratory parameters of clinical evolution for this disorder. We prospectively analysed clinical and immunological characteristics of 77 THI children at initial diagnosis and of 57 patients at follow-up. Memory B cell subsets and in vitro immunoglobulin production were evaluated. Seventy patients (91%) showed clinical symptoms. Patients suffered from infections (91%), allergies (47%) and autoimmune disease (4%). During follow-up 41/57 children (72%) normalized IgG values, mostly within 24 months of age (p

Original language	English
Pages (from-to)	343-352
Number of pages	10
Journal	International Journal of Immunopathology and Pharmacology
Volume	21
Issue number	2
Publication status	Published - Apr 2008

Keywords

In vitro immunoglobulin production
Memory B cell subsets
Primary immunodeficiency
Transient hypogammaglobulinemia of infancy

ASJC Scopus subject areas

Pharmacology

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Moschese, V., Graziani, S., Avanzini, M. A., Carsetti, R., Marconi, M., La Rocca, M., Chini, L., Pignata, C., Soresina, A. R., Consolini, R., Bossi, G., Trizzino, A., Martino, S., Cardinale, F., Bertolini, P., Marseglia, G. L., Zecca, M., Di Cesare, S., Quinti, I., ... Plebani, A. (2008). A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network. International Journal of Immunopathology and Pharmacology, 21(2), 343-352.

A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy : Results from the Italian Primary Immunodeficiency Network. / Moschese, Viviana; Graziani, S.; Avanzini, M. A.; Carsetti, R.; Marconi, M.; La Rocca, M.; Chini, L.; Pignata, C.; Soresina, A. R.; Consolini, R.; Bossi, G.; Trizzino, A.; Martino, S.; Cardinale, F.; Bertolini, P.; Marseglia, G. L.; Zecca, M.; Di Cesare, S.; Quinti, I.; Rondelli, R.; Pietrogrande, M. C.; Rossi, P.; Plebani, A.

In: International Journal of Immunopathology and Pharmacology, Vol. 21, No. 2, 04.2008, p. 343-352.

Research output: Contribution to journal › Article › peer-review

Moschese, V, Graziani, S, Avanzini, MA , Carsetti, R, Marconi, M, La Rocca, M, Chini, L, Pignata, C, Soresina, AR, Consolini, R, Bossi, G, Trizzino, A, Martino, S, Cardinale, F, Bertolini, P, Marseglia, GL , Zecca, M , Di Cesare, S, Quinti, I, Rondelli, R, Pietrogrande, MC, Rossi, P & Plebani, A 2008, 'A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy: Results from the Italian Primary Immunodeficiency Network', International Journal of Immunopathology and Pharmacology, vol. 21, no. 2, pp. 343-352.

Moschese, Viviana ; Graziani, S. ; Avanzini, M. A. ; Carsetti, R. ; Marconi, M. ; La Rocca, M. ; Chini, L. ; Pignata, C. ; Soresina, A. R. ; Consolini, R. ; Bossi, G. ; Trizzino, A. ; Martino, S. ; Cardinale, F. ; Bertolini, P. ; Marseglia, G. L. ; Zecca, M. ; Di Cesare, S. ; Quinti, I. ; Rondelli, R. ; Pietrogrande, M. C. ; Rossi, P. ; Plebani, A. / A prospective study on children with initial diagnosis of transient hypogammaglobulinemia of infancy : Results from the Italian Primary Immunodeficiency Network. In: International Journal of Immunopathology and Pharmacology. 2008 ; Vol. 21, No. 2. pp. 343-352.

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AU - Avanzini, M. A.

AU - Carsetti, R.

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AU - Chini, L.

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AU - Zecca, M.

AU - Di Cesare, S.

AU - Quinti, I.

AU - Rondelli, R.

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AU - Rossi, P.

AU - Plebani, A.

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