A prospective study on duodenogastric reflux and on histological changes in gastric mucosa after cholecystectomy

D. Lorusso, F. Pezzolla, A. Cavallini, C. Messa, P. Giorgio, M. L. Caruso, E. Piccioli, V. Guerra, G. Misciagna

Research output: Contribution to journalArticlepeer-review


The authors carried out a prospective study to evaluate variations with time in postcholecystectomy duodenogastric reflux (expressed as 'fasting bile reflux' in μmol/h) and in gastric mucosal damage. Ten patients underwent (before cholecystectomy, 6 months after surgery and after a median period of 4 years from surgery) a gastric drainage to assess total (enzymatic method) and single (high performance liquid chromatography) intragastric bile acids, and a gastroscopy with biopsies of the antrum and gastric body to assess histological damage to the mucosa. The results showed that there was a progressive increase in the fasting bile reflux of total bile acids with time (precholecystectomy median value 0.295 μmol/h; 6 months control median value 12.045 μmol/h; late control median value 19.9 μmol/h; Friedman test, P = 0.0022). Examination of the gastric mucosa at the three moments of the study showed that histological damage worsened progressively. In fact chronic atrophic gastritis of the antrum was present in 10 percent of cases before surgery and in 50 percent 4 years after, and the prevalence of chronic superficial gastritis of the body progressed from 0 to 40 percent. Studies on larger groups of patients are necessary to evaluate whether these two phenomena are correlated.

Original languageEnglish
Pages (from-to)328-333
Number of pages6
JournalGastroenterologie Clinique et Biologique
Issue number4
Publication statusPublished - 1992


  • cholecystectomy
  • chronic gastric
  • duodenogastric reflux

ASJC Scopus subject areas

  • Gastroenterology


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