A prospective survey of febrile events in hematological malignancies

L. Pagano, M. Caira, G. Rossi, M. Tumbarello, R. Fanci, M. G. Garzia, N. Vianelli, N. Filardi, P. De Fabritiis, A. Beltrame, M. Musso, A. Piccin, A. Cuneo, C. Cattaneo, T. Aloisi, M. Riva, G. Rossi, U. Salvadori, M. Brugiatelli, S. Sannicolò & 5 others M. Morselli, A. Bonini, P. Viale, A. Nosari, F. Aversa

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

The Hema e-Chart prospectively collected data on febrile events (FEs) in hematological malignancy patients (HMs). The aim of the study was to assess the number, causes and outcome of HM-related FEs. Data were collected in a computerized registry that systematically approached the study and the evolution of FEs developing in a cohort of adult HMs who were admitted to 19 hematology departments in Italy from March 2007 to December 2008. A total of 869 FEs in 3,197 patients with newly diagnosed HMs were recorded. Fever of unidentified origin (FUO) was observed in 386 cases (44.4%). The other causes of FE were identified as noninfectious in 48 cases (5.5%) and infectious in 435 cases (50.1%). Bacteria were the most common cause of infectious FEs (301 cases), followed by fungi (95 cases), and viruses (7 cases). Mixed agents were isolated in 32 episodes. The attributable mortality rate was 6.7% (58 FEs). No deaths were observed in viral infection or in the noninfectious groups, while 25 deaths were due to FUO, 16 to bacterial infections, 14 to fungal infections, and three to mixed infections. The Hema e-Chart provided a complete system for the epidemiological study of infectious complications in HMs.

Original languageEnglish
Pages (from-to)767-774
Number of pages8
JournalAnnals of Hematology
Volume91
Issue number5
DOIs
Publication statusPublished - May 2012

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Hematologic Neoplasms
Fever
Surveys and Questionnaires
Mycoses
Hematology
Virus Diseases
Coinfection
Bacterial Infections
Italy
Registries
Epidemiologic Studies
Fungi
Viruses
Bacteria
Mortality

Keywords

  • Epidemiology
  • Febrile events
  • Hematological malignancies
  • Registry

ASJC Scopus subject areas

  • Hematology

Cite this

Pagano, L., Caira, M., Rossi, G., Tumbarello, M., Fanci, R., Garzia, M. G., ... Aversa, F. (2012). A prospective survey of febrile events in hematological malignancies. Annals of Hematology, 91(5), 767-774. https://doi.org/10.1007/s00277-011-1373-2

A prospective survey of febrile events in hematological malignancies. / Pagano, L.; Caira, M.; Rossi, G.; Tumbarello, M.; Fanci, R.; Garzia, M. G.; Vianelli, N.; Filardi, N.; De Fabritiis, P.; Beltrame, A.; Musso, M.; Piccin, A.; Cuneo, A.; Cattaneo, C.; Aloisi, T.; Riva, M.; Rossi, G.; Salvadori, U.; Brugiatelli, M.; Sannicolò, S.; Morselli, M.; Bonini, A.; Viale, P.; Nosari, A.; Aversa, F.

In: Annals of Hematology, Vol. 91, No. 5, 05.2012, p. 767-774.

Research output: Contribution to journalArticle

Pagano, L, Caira, M, Rossi, G, Tumbarello, M, Fanci, R, Garzia, MG, Vianelli, N, Filardi, N, De Fabritiis, P, Beltrame, A, Musso, M, Piccin, A, Cuneo, A, Cattaneo, C, Aloisi, T, Riva, M, Rossi, G, Salvadori, U, Brugiatelli, M, Sannicolò, S, Morselli, M, Bonini, A, Viale, P, Nosari, A & Aversa, F 2012, 'A prospective survey of febrile events in hematological malignancies', Annals of Hematology, vol. 91, no. 5, pp. 767-774. https://doi.org/10.1007/s00277-011-1373-2
Pagano L, Caira M, Rossi G, Tumbarello M, Fanci R, Garzia MG et al. A prospective survey of febrile events in hematological malignancies. Annals of Hematology. 2012 May;91(5):767-774. https://doi.org/10.1007/s00277-011-1373-2
Pagano, L. ; Caira, M. ; Rossi, G. ; Tumbarello, M. ; Fanci, R. ; Garzia, M. G. ; Vianelli, N. ; Filardi, N. ; De Fabritiis, P. ; Beltrame, A. ; Musso, M. ; Piccin, A. ; Cuneo, A. ; Cattaneo, C. ; Aloisi, T. ; Riva, M. ; Rossi, G. ; Salvadori, U. ; Brugiatelli, M. ; Sannicolò, S. ; Morselli, M. ; Bonini, A. ; Viale, P. ; Nosari, A. ; Aversa, F. / A prospective survey of febrile events in hematological malignancies. In: Annals of Hematology. 2012 ; Vol. 91, No. 5. pp. 767-774.
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