A proteinuria cut-off level of 0.7 g /day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: Data from the MAINTAIN Nephritis Trial

Farah Tamirou, Bernard R. Lauwerys, Maria Dall'Era, Meggan Mackay, Brad Rovin, Ricard Cervera, Frédéric A. Houssiau, Daniel Abramowicz, Fabiola Atzeni, Daniel Blockmans, Maria Giovanna Danieli, Luc De Clercq, David D'Cruz, Maria Del Mar Ayala Guttierez, Enrique De Ramon Garrido, Inge Magrethe Gilboe, Filip De Keyser, Michel Delahousse, Gerard Espinosa, Christoph FiehnMarc Golstein, Loïc Guillevin, Marco Hirsch, Alexandre Karras, Philippe Lang, Véronique Le Guern, Martine Marchal, Antonio Marinho, Regina Max, Patrick Peeters, Peter Petera, Radmila Petrovic, Thomas Quémeneur, Frank Raeman, Philippe Remy, Isabelle Ravelingien, Piercarlo Sarzi-Puttini, Shirish Sangle, Maria Tektonidou, Lucia Valiente De Santis, Carlos Vasconcelos, Luc Verresen, Laurence Weiss, René Westhovens

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Although an early decrease in proteinuria has been correlated with good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria value are missing, except a recent analysis performed on patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a target value of 0.8 g/day at month 12 optimised sensitivity and specificity for the prediction of good renal outcome. The objective of the current work is to validate this target in another LN study, namely the MAINTAIN Nephritis Trial (MNT). Methods: Long-term (at least 7 years) renal function data were available for 90 patients randomised in the MNT. Receiver operating characteristic curves were built to test the performance of proteinuria measured within the 1st year as short-term predictor of long-term renal outcome. We calculated the positive and negative predictive values (PPV, NPV). Results: After 12 months of treatment, achievement of a proteinuria

Original languageEnglish
Article numbere000123
JournalLupus Science and Medicine
Volume2
Issue number1
DOIs
Publication statusPublished - Jun 1 2015

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology

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