A quantitative method for assessing the degree of axial proptosis in relation to orbital tissue involvement in graves' orbitopathy

Irene Campi, Guia M. Vannucchi, Andrea M. Minetti, Davide Dazzi, Sabrina Avignone, Danila Covelli, Nicola Currò, Roberto Ratiglia, Claudio Guastella, Lorenzo Pignataro, Paolo Beck-Peccoz, Mario Salvi

Research output: Contribution to journalArticle

Abstract

Purpose: To define a method of quantifying axial proptosis in patients with Graves' orbitopathy (GO) and to validate a score that correlates with the orbital involvement and helps determine the degree of proptosis correction for elective orbital decompression. Design: Retrospective, case series. Participants: The study included 50 patients (group A) and 29 control subjects who underwent orbital computed tomography (CT). The method was then validated in another group of 21 patients with GO (group B). Methods: The orbital area (OA) was measured manually on the central axial section of the CT scan at a level where the lens is visualized. The OA intersects the projection of the globe and delimitates the chord of an arch (globe chord [OC]). The area of the circular sector under the chord (CA) represents the portion of the globe within the orbit. Main Outcome Measures: A CA-to-OA ratio was calculated to reduce the error due to variability of the measurements and to perform correlations with some of the clinical parameters of GO. Results: Measurement error was low (2) and controls (758.5±20.4 mm2; P = not significant). The OC value in patients with GO was 130.2±11.5 mm2, significantly lower than in controls (281.8±9.7 mm2; P

Original languageEnglish
Pages (from-to)1092-1098
Number of pages7
JournalOphthalmology
Volume120
Issue number5
DOIs
Publication statusPublished - May 2013

ASJC Scopus subject areas

  • Ophthalmology

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