A quarter of men with idiopathic oligo-azoospermia display chromosomal abnormalities and microdeletions of different types in interval 6 of Yq11

Liborio Stuppia, Valentina Gatta, Giuseppe Calabrese, Paolo Guanciali Franchi, Elisena Morizio, Cristina Bombieri, Rita Mingarelli, Vincenzo Sforza, Giovanni Frajese, Raffaele Tenaglia, Giandomenico Palka

Research output: Contribution to journalArticlepeer-review

Abstract

Cytogenetic investigations and molecular analysis of the Y chromosome by the polymerase chain reaction amplification of sequence-tagged sites (STS-PCR) technique were performed in 126 patients affected by idiopathic oligo-azoospermia following accurate selection of cases. Seventeen patients evidenced an abnormal karyotype. Fourteen patients with a normal karyotype had microdeletions of the Y chromosome within interval 6. In azoospermic patients microdeletions were scattered along different subintervals, while in oligozoospermic patients they were clustered in subinterval 6E. The size of the deletion was not apparently related to the severity of the disease. These results suggest that cytogenetic analysis and the STS-PCR technique can detect a genetic cause of infertility in about one-quarter of patients with idiopathic oligo-azoospermia.

Original languageEnglish
Pages (from-to)566-570
Number of pages5
JournalHuman Genetics
Volume102
Issue number5
DOIs
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

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