A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: Preliminary data

Paolo Leombruni, Marco Miniotti, Fabrizio Colonna, Chiara Sica, Lorys Castelli, Maria Bruzzone, Simone Parisi, Enrico Fusaro, Piercarlo Sarzi-Puttini, Fabiola Atzeni, Riccardo G. Torta

Research output: Contribution to journalArticle

Abstract

Objective. Fibromyalgia syndrome (FMS) is a chronic disorder characterised by widespread musculoskeletal pain, troubled sleep, disturbed mood, and fatigue. Recently published reviews have demonstrated that it is influenced by various psychological aspects, and antidepressants are now considered the treatment of choice for most patients. The aim of this randomised controlled trial was to compare the effects of duloxetine and acetyl L-carnitine on pain, depression, anxiety and well-being in FMS patients. Methods. Sixty-five female outpatients with FMS diagnosed by a rheumatologist were recruited between January 2011 and May 2012, and randomised to receive duloxetine 60 mg/day or acetyl L-carnitine 1500 mg/day (500 mg t.i.d.). Drug efficacy and side effects were assessed by the same psychiatrist at baseline, and four and 12 weeks later. Results. Both drugs led to a general clinical improvement, with positive effects on pain and depressive symptoms; but neither induced a significant improvement in anxiety. Both drugs had a positive effect on the physical component of the quality of life, but only duloxetine improved the psychological component. Conclusion. Although they need to be confirmed by further studies, these preliminary findings confirm the efficacy of duloxetine, and suggest that acetyl L-carnitine is also efficacious in improving depressive symptoms, pain, and the quality of life of FMS patients.

Original languageEnglish
Pages (from-to)S82-S85
JournalClinical and Experimental Rheumatology
Volume33
Publication statusPublished - 2015

Fingerprint

Acetylcarnitine
Fibromyalgia
Randomized Controlled Trials
Depression
Pain
Anxiety
Quality of Life
Psychology
Musculoskeletal Pain
Drug-Related Side Effects and Adverse Reactions
Pharmaceutical Preparations
Antidepressive Agents
Fatigue
Psychiatry
Sleep
Outpatients
Duloxetine Hydrochloride

Keywords

  • Acetyl L-carnitine
  • Duloxetine
  • Fibromyalgia
  • RCT

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Leombruni, P., Miniotti, M., Colonna, F., Sica, C., Castelli, L., Bruzzone, M., ... Torta, R. G. (2015). A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: Preliminary data. Clinical and Experimental Rheumatology, 33, S82-S85.

A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients : Preliminary data. / Leombruni, Paolo; Miniotti, Marco; Colonna, Fabrizio; Sica, Chiara; Castelli, Lorys; Bruzzone, Maria; Parisi, Simone; Fusaro, Enrico; Sarzi-Puttini, Piercarlo; Atzeni, Fabiola; Torta, Riccardo G.

In: Clinical and Experimental Rheumatology, Vol. 33, 2015, p. S82-S85.

Research output: Contribution to journalArticle

Leombruni, P, Miniotti, M, Colonna, F, Sica, C, Castelli, L, Bruzzone, M, Parisi, S, Fusaro, E, Sarzi-Puttini, P, Atzeni, F & Torta, RG 2015, 'A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients: Preliminary data', Clinical and Experimental Rheumatology, vol. 33, pp. S82-S85.
Leombruni, Paolo ; Miniotti, Marco ; Colonna, Fabrizio ; Sica, Chiara ; Castelli, Lorys ; Bruzzone, Maria ; Parisi, Simone ; Fusaro, Enrico ; Sarzi-Puttini, Piercarlo ; Atzeni, Fabiola ; Torta, Riccardo G. / A randomised controlled trial comparing duloxetine and acetyl L-carnitine in fibromyalgic patients : Preliminary data. In: Clinical and Experimental Rheumatology. 2015 ; Vol. 33. pp. S82-S85.
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