Abstract
This study evaluated the immunogenicity of a double dose of the seasonal virosomal-adjuvanted influenza vaccine (Inflexal V, Crucell, The Netherlands) in 65 previously unvaccinated children aged less than 3 years: 43 received double doses (two doses of 0.50. mL 4 weeks apart) and 22 standard doses (two doses of 0.25. mL 4 weeks apart). Both treatments evoked a response that satisfied the EMEA criteria for adequate immunogenicity for all three vaccine strains, but the double dose had a significantly greater effect on all of the studied parameters of humoral and cell-mediated immune response (p
Original language | English |
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Pages (from-to) | 6137-6144 |
Number of pages | 8 |
Journal | Vaccine |
Volume | 28 |
Issue number | 38 |
DOIs | |
Publication status | Published - Aug 2010 |
Keywords
- Children
- Immunogenicity
- Influenza
- Influenza vaccine
- Reactogenicity
- Virosomal
ASJC Scopus subject areas
- Molecular Medicine
- Immunology and Microbiology(all)
- Infectious Diseases
- Public Health, Environmental and Occupational Health
- veterinary(all)