A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months

Susanna Esposito; Paola Marchisio; Filippo Ansaldi; Sonia Bianchini; Michela Pacei; Elena Baggi; Daria Trabattoni; Giancarlo Icardi; Nicola Principi

doi:10.1016/j.vaccine.2010.07.041

A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months

Susanna Esposito, Paola Marchisio, Filippo Ansaldi, Sonia Bianchini, Michela Pacei, Elena Baggi, Daria Trabattoni, Giancarlo Icardi, Nicola Principi

Research output: Contribution to journal › Article

Abstract

This study evaluated the immunogenicity of a double dose of the seasonal virosomal-adjuvanted influenza vaccine (Inflexal V, Crucell, The Netherlands) in 65 previously unvaccinated children aged less than 3 years: 43 received double doses (two doses of 0.50. mL 4 weeks apart) and 22 standard doses (two doses of 0.25. mL 4 weeks apart). Both treatments evoked a response that satisfied the EMEA criteria for adequate immunogenicity for all three vaccine strains, but the double dose had a significantly greater effect on all of the studied parameters of humoral and cell-mediated immune response (p

Original language	English
Pages (from-to)	6137-6144
Number of pages	8
Journal	Vaccine
Volume	28
Issue number	38
DOIs	https://doi.org/10.1016/j.vaccine.2010.07.041
Publication status	Published - Aug 2010

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Keywords

Children
Immunogenicity
Influenza
Influenza vaccine
Reactogenicity
Virosomal

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
Infectious Diseases
Public Health, Environmental and Occupational Health
veterinary(all)

Cite this

Esposito, S., Marchisio, P., Ansaldi, F., Bianchini, S., Pacei, M., Baggi, E., Trabattoni, D., Icardi, G., & Principi, N. (2010). A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months. Vaccine, 28(38), 6137-6144. https://doi.org/10.1016/j.vaccine.2010.07.041

A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months. / Esposito, Susanna; Marchisio, Paola; Ansaldi, Filippo; Bianchini, Sonia; Pacei, Michela; Baggi, Elena; Trabattoni, Daria; Icardi, Giancarlo; Principi, Nicola.

In: Vaccine, Vol. 28, No. 38, 08.2010, p. 6137-6144.

Research output: Contribution to journal › Article

Esposito, S, Marchisio, P, Ansaldi, F, Bianchini, S, Pacei, M, Baggi, E, Trabattoni, D, Icardi, G & Principi, N 2010, 'A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months', Vaccine, vol. 28, no. 38, pp. 6137-6144. https://doi.org/10.1016/j.vaccine.2010.07.041

Esposito, Susanna ; Marchisio, Paola ; Ansaldi, Filippo ; Bianchini, Sonia ; Pacei, Michela ; Baggi, Elena ; Trabattoni, Daria ; Icardi, Giancarlo ; Principi, Nicola. / A randomized clinical trial assessing immunogenicity and safety of a double dose of virosomal-adjuvanted influenza vaccine administered to unprimed children aged 6-35 months. In: Vaccine. 2010 ; Vol. 28, No. 38. pp. 6137-6144.

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10.1016/j.vaccine.2010.07.041