A randomized clinical trial on the efficacy of physical rehabilitation in multiple sclerosis patients: Interim analysis

A. Solari, L. Coggiola, L. Collâ, M. Eoli, M. Farinotti, G. Filippini, P. Gasco, L. La Mantia, L. Mendozzi, C. Milanese, A. Salmaggi

Research output: Contribution to journalArticlepeer-review

Abstract

From January 1996 all consecutive clinically definite multiple sclerosis (MS) outpatients admitted to our Institute giving written informed consent were randomly assigned to a three-weeks inpatient focused rehabilitation program (study treatment) or to a selfperformed exercise program (control treatment). Outcome measures consisted in neurological impairment assessed with Kurtzke's Expanded Disability Status Scale (EDSS) and the Ambulation Index, disability assessed with the Functional Independence Measure, and self-perceived health status assessed by the Short Form 36 Health Survey. Blind evaluation took place at baseline, at the end of the treatment period,and at weeks 9 and 15. To date, 48 out of 302 eligible patients (25 assigned to the inpatient rehabilitation and 23 to the self-performed program) have completed the study. One patient assigned to the control treatment dropped out. Mean age is 48 years, 26 (54%) are female and median EDSS score is 5.0 (range, 3.0 to 6.5). All data were analysed according to the original randomization assignment.

Original languageEnglish
Pages (from-to)54
Number of pages1
JournalItalian Journal of Neurological Sciences
Volume18
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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